左氧氟沙星两种给药方法治疗淋病合并非淋菌性尿道炎疗效观察  

Therapeutic effect of levofloxacin of two regimens on gonocchea with non-gonorrhea urethritis

作　　者：杜红[1] 黄又宁[1] 

机构地区：[1]广西南宁市第四人民医院,南宁530023

出　　处：《中南药学》2005年第4期248-250,共3页Central South Pharmacy

摘　　要：目的观察左氧氟沙星同剂量不同给药方法治疗淋病合并非淋菌性尿道炎的疗效。方法72例患者随机分为2组,A组予左氧氟沙星0.5g,1次·d-1,口服,连服6d;B组予左氧氟沙星0.1g,3次·d-1,口服,连服10d。结果A、B2组治愈率、总有效率分别为69.4%(25/36),94.4%(34/36)和44.4%(16/36)、75%(27/36),有显著差异(治愈率:χ2=4.59,P<0.05;总有效率:χ2=6.63,P<0.05);不良反应发生率分别是:A组22.2%(8/36)和B组13.89%(5/36),无显著性差异(χ2=0.083,P<0.05)。结论口服左氧氟沙星治疗淋病合并非淋性尿道炎,在用药总剂量相等的条件下,大剂量每日1次疗法优于小剂量每日3次疗法。OBJECrlVE To observe the treatment effect of gonocchea with non-gorcoccal urethritis by levofloxacin at the same course but different single doses. METHODS Seventy-two patients were randomly divided into 2 groups. Group A was treated with levofloxacin 500 mg, once daily for 6 days. Group B was treated with levofloxacin 100 mg,three times daily for 10 days.RESULTS The cure rate, and the efficacy rate in group A were 69.4%0 （25/36）, and 94.4% （34/36） respectively, and those in group B were 44.4% （16/36）, and 75% （27/36） respectively. A significant difference was found between the 2 groups （P〈0.05 for cure rate： x^2 =4.31 ; P〈0.05 for efficacy rate： x^2=6.63）. The adverse reactions were 22.2% （8/36） in group A, and 13. 89% （5/36） in group B, no significant difference was found between the 2 groups （x^2=0.84. P〉0.05）. CONCLUSIONS The regimen of 500 mg once daily is superior to that of 100 mg three times daily with the same course dose of levofloxacin.

关 键 词：淋病 非淋菌性尿道炎 左氧氟沙星 

分 类 号：R978[医药卫生—药品]