颅脑外伤后早期低氧应激肽和皮质醇的表达及意义  

Expression of hypoxic stress peptide and cortisol in early period after craniocerebral trauma and its significance

作　　者：曾平[1] 胡娟[1] 王超[1] 胡宗海[1] 

机构地区：[1]成都军区总医院检验科,四川成都610083

出　　处：《西南国防医药》2005年第4期369-371,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：四川省教育厅重点课题(000221)

摘　　要：目的:研究颅脑外伤后早期人体血清低氧应激肽效应表达及临床意义.方法:收集本院急性颅脑外伤(主要为车祸伤)患者受伤后12～48 h以内血清,并于-40℃保存待检.采用比色法检测血清低氧应激肽含量,皮质醇含量检测采用放射免疫法.结果:颅脑外伤后早期有低氧应激肽表达,皮质醇含量增高.结论:颅脑外伤早期低氧应激肽表达可能与皮质醇含量增高有关.Objective： To investigate the expression of hypoxic stress peptide and cortisol in early period after craniocerebral trauma and its clinical significance. Methods： The samples of sera from the patients with craniocerebral trauma in the early period（〈48h） were collected and stored at -40℃. The level of hypoxic stress peptide was detected with rapid examination method; the level of cortisol was done by radioimmunoassay. There was a positive correlation between the expression of hypoxic stress peptide and the content of cortisol （r=0. 98, P〈0.01）. Results： The expression of hypoxic stress peptide was found and the level of cortisol increased in these patients.Conclusion：During the early period of cranioccerebral trauma.the expression of hypoxis stress peptide was relared with the content of cortisol.

关 键 词：颅脑外伤 低氧应激肽 皮质醇 

分 类 号：R651.1[医药卫生—外科学]