米非司酮配合孕激素 雄激素治疗更年期功血56例分析  

COMBINED USE OF MIFEPRISTONE PROTESTOGEN AND ANDROGEN IN TREATING 56 CASES OF CLIMACTERIC DYSFUNCTIONAL UTERINE BLEEDING

作　　者：张立霞[1] 宋敏[1] 

机构地区：[1]临沂市中医医院,山东临沂276002

出　　处：《临沂医学专科学校学报》2005年第4期259-261,共3页Journal of Linyi Medical College

摘　　要：目的探讨应用米非司酮配合孕激素、雄激素治疗更年期功血的疗效。方法月经或诊刮后第3天开始应用米非司酮10mg/d,连续3个月为1疗程,疗程结束前10d加用安宫黄体酮10mg/d,甲基睾丸素10mg/d,观察用药期间及撤药后阴道流血情况及子宫内膜病理变化,患者年龄、疗程与诱导绝经例数的关系等。结果用药期间患者均闭经,停药后90%的患者月经量少于或等于正常月经量,无撤药性大出血病例。子宫内膜转化良好,无增生过长现象。56例中已有33例成功诱导绝经,疗程多少与诱导绝经数成正比,年龄大小与诱导绝经所需疗程成反比。合并子宫肌瘤患者肌瘤均有不同程度的缩小,无其他不良反应。结论应用米非司酮配合孕激素、雄激素治疗更年期功血,能防止子宫内膜过度增生,减少撤药性大出血风险,控制肌瘤生长,并能有效地诱导绝经,达到治愈目的。Objective To explore the curative effects of the combined use of mifepristone, protestogen and androgen on climacteric dysfunctional uterine bleeding. Methods 10mg Mifepristone was used daily 3 days after menses and dignostic curretage, 3 month as a course. 10mg medroxyprogesterone a day and 10mg methyhestosterone a day were added to the above therapy 10 days before the course ended. Dysfunctiond uterine bleeding and endometrial pathological changes were observed during the drug- admistering period and after the course of treatment ended. The relationship between menopause and the age or the course of treatment were studied. Results All patients showed menopause. 90 % of the patients got normal menses or the menses with less bleeding. No massive hemorrhage occurred after the treatments. Endometria recovered well and no hyperplasia take place. Of the 56 patients,33 cases successfully got induced menopause. The frequency of the course of treatment is in positive proportion to the number of cases of menopause, while in negative proportion to age. Hysteromyoma shrank to different extent. No side effects were discovered. Conclusion Combined use of mifepristone protestogen and androgen in treating climateric dysfunctional uterine bleeding can prevent endometrial hyperplasia, reduce massive hemorrhage, control hysteromyoma and effectively induce menopause.

关 键 词：功能性子宫出血 更年期 米非司酮 孕激素 雄激素 

分 类 号：R711.52[医药卫生—妇产科学]