中药复方对模拟失重兔血流变特性及循环系统的调节作用  

Regulative Effects of Chinese Herb-compound on Blood Rheology and Circulatory System of Rabbits under Simulated Weightlessness

作　　者：石宏志[1] 李勇枝[1] 沈羡云[1] 范全春[1] 白桂娥[1] 

机构地区：[1]航天医学工程研究所,北京100094

出　　处：《航天医学与医学工程》2005年第4期251-254,共4页Space Medicine & Medical Engineering

基　　金：中国载人航天工程项目资助

摘　　要：目的研究中药复方对模拟失重兔血流变及循环系统的调节作用,为防护失重对心血管功能的不良影响提供依据。方法用兔头低位(-20°)倾斜9d模拟失重,观察中药复方对兔血液流变学、血脂指标及立位耐力的影响。结果兔模拟失重后红细胞压积减少,红细胞变形能力明显下降,纤维蛋白原含量有增加趋势;胆固醇和低密度脂蛋白明显增加,甘油三脂有轻度增高趋势。中药复方对血液流变学指标改善不明显,但有降低甘油三脂的趋势,对胆固醇的增加也有抑制的趋势。在负压-立位实验过程中,对照组兔模拟失重后立位耐受时间减少,中止实验前出现了ST段下移、T波倒置及心律紊乱等明显的心肌缺血性改变;而中药组兔心率平稳,心电图缺血性改变不明显,立位耐受时间增加。结论中药复方对模拟失重兔的立位耐力降低具有显著的防护作用,同时还能改善血脂代谢,从整体上对机体各系统进行调节,提高了机体适应外界不良环境、抵御不良刺激的能力。Objective To investigate effects of Chinese herb-compound on blood rheology and circulatory system of rabbits under simulated weightlessness in order to provide bases for protecting against the influence of simulated weightlessness on cardiovascular function. Method Rabbits were exposed to head-down tilt （ HDT -20~） for 9 d to simulate weightlessness. The effect of Chinese herb-compound on indices related to blood rheology, blood-fat and orthostatic tolerance in these rabbits were examined. Result After head-down tilt, hematocrit value and red blood cells deformability decreased significantly; cholesterol and low density lipoprotein increased markedly; plasma fibrinogen content and triglyceride showed increasing trend. Administration of the Chinese herb-compound didn＇t improve the blood rheology indices, but showed a trend to decrease triglyceride and to inhibit the increase of cholesterol. In the head-up tilt （HUT） plus lower body negative pressure （LBNP） experiment, orthostatic tolerance time of the rabbits in the control group decreased, and myocardial ischemic changes in ECG, such as dropped ST segment, inverse T wave, and arrhythmia were observed. While in the Chinese herb-compound group, the heart rate of the rabbits kept smooth, ischemic changes in ECG were not clear, and orthostatic tolerance time increased. Conclusion The Chinese herb-compound shows an effect of preventing orthostatic tolerance from decreasing, and improves blood-fat metabolism. It regulates different human systems on the whole,and increases ability of adaption to ill environment.

关 键 词：失重模拟 中药复方 血液流变学 血脂 立位耐力 

分 类 号：R852.22[医药卫生—航空、航天与航海医学] R856.2[医药卫生—临床医学]