血管紧张素Ⅱ2型受体基因多态性与男性高血压病的相关研究  

Relation between the angiotensin Ⅱ type 2 receptor polymorphism and essential hypertension in men

作　　者：乔卫卫[1] 张奎星[1] 刘同宝[1] 刘国祥[2] 徐世杰 

机构地区：[1]济南山东大学山东省立医院心内科循环西组 [2]济南市第五人民医院 [3]国家人类基因组南方研究中心遗传组

出　　处：《中华心血管病杂志》2005年第7期592-594,共3页Chinese Journal of Cardiology

摘　　要：目的检测血管紧张素Ⅱ2型受体基因的单核苷酸多态性(SNP)并探讨其与山东地区汉族男性高血压病(EH)之间的关系。方法应用直接测序的方法在随机选择的20例男性EH中对血管紧张素Ⅱ2型受体基因作SNP的筛查,同时在96例EH男性患者和107例正常对照男性人群中评价这些SNP与EH的关系。结果共发现了7个SNP,其中有4个SNP在本研究中初次发现。对其中2个SNP(A1675G和T1334C)进行病例对照研究,发现A1675G位点上男性EH患者中A等位基因频率与正常对照组相比差异有统计学意义(EH组A等位基因频率为49·0%,正常组为34·6%,P<0·05)。结论血管紧张素Ⅱ2型受体基因的A1675G单核苷酸多态性可能与山东地区男性EH患者相关。Objective To identify single nucleotide polymorphisms （SNP） of the angiotensin Ⅱ type 2 receptor （AGTR2） gene, and to determine whether the AGTR2 polymorphisms are associated with essential hypertension in a male Chinese population. Methods Direct DNA sequencing was performed in 20 subjects. 96 male hypertensive patients and 107 normal controls were included to assess the contribution of the SNP of AGTR2 gene to hypertension. Results Seven SNP of the AGTR2 gene were identified, of which 4 were reported for the first time. A case-control study including two polymorphisms （A1675G and T1334C） showed a significant increase in the A1675 allele frequency among male hypertensive subjects as compared with normotensive subjects （ 49. 0% vs 34. 6%, P 〈 0. 05 ） . Conclusion The AGTR2 A1675G polymorphism might be involved in the development of essential hypertension in male Chinese.

关 键 词：高血压 受体 血管紧张素 多态性 单核苷酸 受体基因多态性 血管紧张素Ⅱ 男性人群 相关研究 高血压病 单核苷酸多态性(SNP) 2型 

分 类 号：R544.1[医药卫生—心血管疾病]