金鸡纳生物碱电喷雾质谱裂解规律研究  

Study on the Dissociation Laws of Four Alkaloids in Cinchona by Electrospray Ionization MS

作　　者：韩凤梅[1] 陈琳[1] 陈勇[1] 

机构地区：[1]湖北大学生命科学学院中药生物技术实验室,武汉430062

出　　处：《分析科学学报》2005年第4期390-392,共3页Journal of Analytical Science

基　　金：湖北省青年杰出人才科学基金(No.2002AC004)

摘　　要：利用电喷雾离子阱质谱(ES-ITMS)技术进行了金鸡纳中4种喹啉类生物碱(奎宁、奎尼定、辛可宁和辛可尼定)的电喷雾质谱研究。在优化的质谱条件下,正离子全扫描时,4种生物碱都易形成带一个质子的分子离子;进一步碰撞诱导解离四种母离子,二级质谱表明羟基丢失、奎宁环断裂及重排为其主要裂解方式。The MS behaviors and dissociation laws of four alkaloids in Cinchona were studied by direct infusion into electrospray ion trap mass spectrometry （ESI-ITMS）. The analytes （dissolved in methanol） easily formed molecular ions （[M＋H]^＋） in positive detection mode. In CID detection mode, the simple substituents such as -OH were easy to loss in the four alkaloids, and the dissociation and rearrangement of quinuclidine were also the primary behaviors of those analytes.

关 键 词：奎宁 奎尼定 辛可宁 辛可尼定 电喷雾离子阱质谱 裂解规律 

分 类 号：O657.63[理学—分析化学] Q946.88[理学—化学]