VEGF及其受体在妊娠高血压综合征胎盘的表达  

EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND ITS RECEPTORS IN THE PLACENTA OF PIH WOMEN

作　　者：杨宗利[1] 刘佩秋[1] 杨晓菊[1] 彭伟[1] 叶元华[1] 

机构地区：[1]青岛大学医学院附属医院妇产科,山东青岛266003

出　　处：《青岛大学医学院学报》2005年第2期146-148,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的探讨血管内皮生长因子(VEGF)在妊娠高血压综合征(妊高征)发病中的作用。②方法以免疫组织化学方法观察VEGF及其受体酪氨酸激酶-1(FLT-1)在正常妊娠及妊高征胎盘绒毛中的表达。③结果VEGF主要表达于胎盘绒毛滋养叶细胞;FLT-1在胎盘中表达于滋养叶细胞、绒毛间质和血管内皮细胞;妊高征组胎盘中VEGF、FLT-1的表达均较正常晚期妊娠组弱,差异有显著性(t=2.358、2.447,P<0.05)。④结论胎盘中VEGF及FLT-1表达的降低,可能致胎盘浅表着床,从而可能诱发妊高征。Objective To explore the expression of vascular endothelial growth factor（VEGF） in the genesis of pregnancy-induced hypertension（PIH）. Methods Expressions of VEGF and its receptor FLT-1 were measured immunohistochemically in placental villi in women with normal pregnancy and PIH. Results VEGF was mainly expressed in the trephocytes of the placenta villi. FLT-1 was expressed in the trephocytes in normal term placenta, villous interstitial substance, and vascular endothelial cells. In PIH group, the distribution of VEGF and FLT-1 immunoreactivity was significantly reduced （t=2.358,2.447; P〈0.05）. Conclusion The reduced expression of VEGF and FLT-1 in placenta might lead to superficial implantation and the genesis of PIH.

关 键 词：妊娠并发症 心血管 胎盘 血管内皮生长因子 受体 蛋白质酪氨酸激酶类 

分 类 号：R714.246[医药卫生—妇产科学]