病毒性心肌炎患儿血清GrB、sFasL因子的变化及意义  

Role of serum GrB and sFasL in the development of virus myocarditis in children

作　　者：朱艳萍[1,2] 韩波[3] 韩秀珍[3] 马连月[2] 陆诗祥[2] 孙文英[2] 

机构地区：[1]山东大学医学院,山东济南250012 [2]聊城市人民医院 [3]山东省立医院

出　　处：《山东医药》2005年第22期1-2,共2页Shandong Medical Journal

基　　金：山东省卫生厅卫生科研项目(2001年第CAIDBA11号)

摘　　要：目的研究病毒性心肌炎(VMC)患儿外周血颗粒酶(GrB)、可溶性Fas配体(sFasL)水平及与心肌酶的关系,探讨其在VMC发病机制中的作用。方法采用酶联免疫吸附试验(ELISA)分别对40例VMC患儿和40例正常对照儿童外周血GrB、sFasl水平进行定量研究。结果①VMC组外周血GrB、sFasL水平高于正常对照组,差异有显著意义(P<0.05);②VMC组GrB、sFasL水平升高者.各项心肌酶异常百分数均增高(P< 0.05)。结论VMC患儿外周血GrB、sFasL水平增高可能与心肌损害及致心肌细胞凋亡有关.提示GrB、sFasL 在VMC发病机制中起一定作用。Objective： To evaluate the role of the serum GrB and sFasl in the development of VMC and correlation with the serum myocardium enzyme. Methods：40 children with VMC were selected. There were 30 healthy children as controls. By using the method of ELISA, the level of serum GrB and sFasL was assayed. Results：The levels of serum GrB and sFasL in patients with VMC were higher than those in the healthy group （P〈0.05）. There was a positive correlation between the level of serum GrB, sFasL and myocardium enzyme. Conclusion： The higher level of serum GrB and sFasL may be important to the development of virus myocarditis in children.

关 键 词：病毒性心肌炎 儿童 颗粒酶 可溶性FAS配体 

分 类 号：R542.2[医药卫生—心血管疾病]