含丝氨酸和组氨酸残基手性肽核酸单体的合成  

Synthesis of Chiral Peptide Nucleic Acid Monomers Containing Serine and Histidine Residues

作　　者：孟庆国[1] 褚征[1] 刘克良[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《有机化学》2005年第8期977-981,共5页Chinese Journal of Organic Chemistry

摘　　要：设计合成了含组氨酸残基碱基为胸腺嘧啶的手性肽核酸单体,咪唑氨基的最终保护基为2,4-二硝基苯基(Dnp).对文献合成方法进行了适当改进,制备了两种含丝氨酸和组氨酸残基碱基为腺嘌呤的手性肽核酸单体,以上化合物均可作为制备手性肽核酸的基本构建单元.A chiral peptide nucleic acid （PNA） monomer containing histidine residue and thymine has been designed and synthesized employing 2,4-dinitrofluorobenzene to protect the NH group of imidazole. Other two PNA monomers containing serine and histidine residues and adenine have been prepared with the modified method to literatures. These compounds could be used as building blocks for chiral peptide nucleic acid analogues.

关 键 词：丝氨酸 组氨酸残基 手性肽核酸 单体 合成 胸腺嘧啶 

分 类 号：TQ464.7[化学工程—制药化工]