微波促进下6-氨基-4-芳基-5-氰基-3-甲基-1-苯基吡啶[2,3-c]并吡唑的合成  

Synthesis of 6-Amino-4-aryl-5-cyano-3-methyl-1-phenylpyridino-[2,3-c]pyrazole under Microwave Irradiation

作　　者：朱松磊[1] 屠树江[1] 李团结[1] 章晓镜[1] 纪顺俊[2] 张勇[2] 

机构地区：[1]徐州师范大学化学系 [2]苏州大学化学化工学院,苏州215006

出　　处：《有机化学》2005年第8期987-990,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20372057);江苏省自然科学基金(No.BK2001142);江苏省苏州大学化学及化学工程有机合成重点实验室开放基金(No.S8109111);江苏省药用植物生物技术重点实验室基金(No.01AXL14)资助项目

摘　　要：5-氨基-3-甲基-1-苯基吡唑与芳亚甲基丙二腈在少量乙二醇中,经微波辐射得到6-氨基-4-芳基-5-氰基-3-甲基-1-苯基吡啶[2,3-c]并吡唑衍生物,反应4～8min完成,产率为71%～90%,产物结构通过红外、核磁共振、元素分析及单晶X射线分析表征.A series of 6-amino-4-aryl-5-cyano-3-methyl-l-phenylpyridino[2,3-c]pyrazole derivatives were synthesized by the reaction of 5-amino-3-methyl-l-phenylpyrazole with arylidene derivatives of malononitrile under microwave irradiation. The reaction was completed in 4～8 min with 71%～90% yields. All the products were characterized by IR, ^1H NMR spectra and elemental analysis. 3j was determined by the X-ray diffraction.

关 键 词：6-氨基-4-芳基-5-氰基-3-甲基-1-苯基吡啶[2 3-c]并吡唑 合成 微波辐射 晶体结构 

分 类 号：TQ253.2[化学工程—有机化工]