α-(1,3,4-噻二唑-5-基)氨基烃基膦酸酯的合成及生物活性  

Synthesis and Biological Activity of α-(1,3,4-Thiadiazol-5-yl)-aminoalkyl Phosphonates

作　　者：曹蕾[1] 汪焱钢[1] 宋新建[1] 刘国华[1] 

机构地区：[1]华中师范大学化学学院

出　　处：《有机化学》2005年第8期1007-1010,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20072009)资助项目

摘　　要：以5-氨基-2-巯基的席夫碱与亚磷酸二乙酯反应,合成了15个新的α-(1,3,4-噻二唑-5-基)氨基烃基膦酸酯,初步的生物活性测试表明部分目标化合物具有较好的植物生长调节活性,其中2,4-二氯苯甲醛、呋喃甲醛和吲哚甲醛的席夫碱生成的α-氨基烃基膦酸酯具有较好的生长素活性.Fifteen new α-（1,3,4-thiadiazol-5-yl）aminoalkyl phosphonates have been synthesized by addition reaction of diethyl phosphite to the corresponding Schiff bases of 5-amino-2-mecapto-l,3,4-thiadiazole.Preliminarily biological activity tests show that some target compounds have good activity as plant growth regulator, particularly α-aminoalkyl phosphonates of 2,4-dichlorobenzaldehyde, furfuraldehyde and indolylaldehyde have better auxin activity.

关 键 词：α-(1 3 4-噻二唑-5-基)氨基烃基膦酸酯 合成 生物活性 植物生长调节活性 席夫碱 生长素 

分 类 号：TQ450.1[化学工程—农药化工]