替米沙坦治疗慢性充血性心力衰竭疗效观察  

Clinical study of telmisartan in treatment of chronic heart failure

作　　者：张志伟[1] 周东容[1] 焦海燕[1] 徐验[1] 

机构地区：[1]深圳市孙逸仙心血管医院心内科,广东深圳518020

出　　处：《岭南心血管病杂志》2005年第4期259-261,共3页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨慢性充血性心力衰竭时替米沙坦对病人肾素活性、血管紧张素Ⅱ水平和血流动力学的影响。方法120例老年慢性充血性心力衰竭病人随机分为替米沙坦组和依那普利组各60例。疗程12周。测定肾素活性、血管紧张素Ⅱ水平,用超声心动图测定治疗前、治疗12周后心功能、血流动力学变化。结果两组治疗12周后,心功能改善至Ⅰ-Ⅱ级,多项血流动力学指标如左心室射血分数、短轴缩短率、每搏量、心输出量、心脏指数、左心室舒张末期内径等均获改善,与治疗前比较差异有统计学意义(P<0.05),治疗前、后两组比较差异均无统计学意义(P>0.05)。治疗后,替米沙坦组血管紧张素Ⅱ水平改变无统计学意义(P>0.05);但依那普利组血管紧张素Ⅱ水平降低。结论与依那普利比较,替米沙坦治疗老年慢性充血性心力衰竭疗效相似,改善临床症状和多项血流动力学指标,并且有较好的耐受性。Objectives To study the effects of telmisartan on renin, angiotensin Ⅱ and hemodynamics in patients with chronic heart failure （CHF）. Methods 120 old patients with CHF were randomized to either telmisartan or enalapril groups, each group had 60 patients. The treating course was 12 weeks. The renin activity and angiotensin Ⅱ level in serum were determined. Hemodynamics and cardiac function were assessed by echocardiography at pre- or post-treatment. Results Hemodynamics and cardiac function were improved after treatment 12 weeks in both groups. The deference of comparison with pre-treatment was significant （P〈0.05）.There was no difference at pre- or post-treatment between both groups（P〉0.05）. Conclusions This study shows that oral telmisartan administered to old patients with CHF results in beneficial clinical features and hemodynamic indices, similarly with enalapril, and it is well tolerated.

关 键 词：心力衰竭 替米沙坦 依那普利 心功能 血流动力学 

分 类 号：R541.61[医药卫生—心血管疾病] R972.4[医药卫生—内科学]