Th_1类细胞因子γ-干扰素治疗喘憋性肺炎30例临床研究  

Clinical Study about 30 Cases of Wheezing Pneumonia Intervened with γ-IFN

作　　者：崔爱华[1] 郭永清[2] 李晓燕[1] 吕学云[1] 周阔[1] 樊敏华[1] 

机构地区：[1]山东省聊城市人民医院,252000 [2]聊城职业技术学院

出　　处：《医学理论与实践》2005年第8期892-895,共4页The Journal of Medical Theory and Practice

摘　　要：目的:探讨喘憋性肺炎和哮喘发病机理的共同点,观察γ-IFN早期干预的效果.方法:选取2003年9月～2004年8月在我科住院、门诊就诊、健康查体的喘憋性肺炎患儿60例(干预组30例,非干预组30例),哮喘患儿30例,普通肺炎患儿30例,正常对照30例为研究对象.各组患儿在年龄、性别上无统计学差异.IgE测定采用ELISA方法.统计学处理选用t检验、χ2检验.结果:(1)喘肺患儿血清IgE水平高于普通肺炎组和正常对照组,与哮喘组无显著差异.(2)γ-IFN治疗后喘肺患儿血清IgE水平低于非干预组;喘鸣音消失时间和住院日缩短;(3)随访9个月,进展为哮喘的患儿比率明显低于非干预组.结论:喘肺患儿和哮喘患儿一样存在高IgE状态,γ-IFN能降低喘肺患儿的血清IgE水平,缩短病程,降低进展为哮喘的危险度.Objective： To explore the same mechanism between wheezing pneumonia and asthma, and evaluate the effect of early intervention with γ- IFN. Methods： Serum IgE concentrations were measured with ELISA way in 30 infants with asthma and 30 infants with cortanon pneumonia and 30 healthy controls and 60 infants with wheezing pneumonia. There was no statistical difference in age and sex in each group. All the wheezing pneumonia infants were observed terms of wheezing and duration of hospitalization and followed - up. We chose t test, χ^2 test according to statistics. Results： （ 1 ） Seurm IgE concentrations were significantly higher in wheezing pneumonia and asthma than other groups, but no difference was found between wheezing pneumonia and asthma. （2） Seurm IgE level was significantly lower after γ- IFN intervention, terms of wheezing and duration of hospitalization were shortened. （3） In the following 9 months, the rate of becoming asthma was significantly lower in γ- IFN intervention group than no γ- IFN intervention group. Conclusion： The wheezing pneumonia infant has the same higher serum IgE level as asthma infant, γ- IFN can reduce serum IgE level, shorten the duration of hospitalization and bring down the risk of becoming asthma.

关 键 词：喘憋性肺炎 哮喘 IgE Γ-干扰素 Γ-IFN TH1类细胞因子 干扰素治疗 临床研究 IGE水平 肺炎患儿 

分 类 号：R725.631[医药卫生—儿科] R512.62[医药卫生—临床医学]