急性一氧化碳中毒患者血浆S-100蛋白水平及其临床意义  

Evaluation of S-100 Protein in Plasm Fluid of the Patients with Acute Carbon Monoxide Poisoning

作　　者：李复雄[1] 李卫军[1] 廖长征[1] 王晓川[1] 

机构地区：[1]广东省深圳市龙岗中心医院急诊科,518116

出　　处：《医学理论与实践》2005年第8期900-901,共2页The Journal of Medical Theory and Practice

摘　　要：目的:观察急性一氧化碳中毒患者血浆S-100蛋白的浓度,并评价其临床意义。方法:将24例急性一氧化碳中毒患者分为三组:A组(轻度中毒组)、B组(中度中毒组)和C组(重度中毒组),应用ELISA法对24例急性一氧化碳中毒患者的血浆S-100蛋白水平进行检测,并与20例对照组(D组)进行比较。结果:轻度中毒组血浆S-100蛋白水平无明显升高(P>0·05),重度组与中度组血浆S-100蛋白水平均明显高于对照组(P<0·01),且重度组血浆S-100蛋白水平明显高于中度组(P<0·05);迟发性脑病发生组血浆中S-100蛋白水平与未发生组比较差异无显著性(P>0·05)。结论:急性一氧化碳中毒患者血浆S-100蛋白水平的检测,有助于评估急性一氧化碳中毒急性期脑组织受损的严重程度,但不能早期预测迟发性脑病的发生。Objective：To observe plasm S - 100 protein levels in patients with acute carbon monoxide poisoning and explore its clinical significance. Methods：24 patients with acute carbon monoxide poisoning were randomly divided into three groups： group A （gentleness poisoning group）, group B（ moderate poisoning group）and group C（ severe poisoning group）. Plasma S- 100 preptein levels of 24 patients and 20 cases in normal control group were detected respectively with ELISA. Results： Plasm S- 100 protein level in group A was not higher than that in normal control group （ P 〉 0.05） ; The levels of plasm S - 100 protein in group B and group C were significantly higher than ,,bat in control group （ P 〈 0.01） ,Plasm S - 100 protein level in group C was obviously higher tban that in group B aLso.There was no statistically significant difference in the plasma S- 100 protein level between the patients with delayed encephalopathy and those without delayed encephalopathy （P 〉 0.05）. Conclusion： Determination of plasm S- 100 protein level can contribute to assessing the severe degree of acute carbon monoxide poisoning, but it can not predict the occurrence of delayed encephalopathy.

关 键 词：一氧化碳中毒 S-100蛋白 脑病 

分 类 号：R446.112[医药卫生—诊断学]