可降解聚乳酸/罗红霉素膜剂中药物体外释放性能研究  

Study on the Release Behavior of Biodegradable Polylactic acid / Roxithromycin Membrane in vitro

作　　者：付东伟[1] 闫玉华[1] 

机构地区：[1]武汉理工大学生物中心,湖北武汉430070

出　　处：《生物骨科材料与临床研究》2005年第4期9-11,共3页Orthopaedic Biomechanics Materials and Clinical Study

摘　　要：目的考察罗红霉素聚乳酸药膜的体外释药性能。方法采用紫外分光光度法测定溶液中罗红霉素的含量。测定波长为482nm。结果在不到三周的时间内,药物释放量超过80%。在最可能形成粘连的5-7d内,药物充分发挥了作用。结论该药膜对罗红霉素有一定的缓释作用,可用于防治术后粘连。Objective To study the release ofpolylactic acid/roxithromycin membrane in vitro. Methods Ultraviolet-visible spectrophotometer was applied for analyzing roxithromycin concentration in the solution. The wavelength was 482nm. Results In less than 3weeks, the capacity of release overruned 80%. The roxithromycin was be used adequately in 5-7d when the adhesion easily formed. Conclu sio n The Polylactic acid / roxithromycin membrane showed significant sustained release effect and it can be used for prevention of postoprative adhesion.

关 键 词：聚乳酸 罗红霉素 紫外分光光度法 药物释放 

分 类 号：R94[医药卫生—药剂学]