阿司匹林对压力负荷性心肌肥厚大鼠左心室重构的影响  

Influence of aspirin on rats with pressure overloaded hypertrophic myocardium

作　　者：曾量波[1] 梁子敬[1] 王鹏鲲[1] 叶政[1] 陈国勤[1] 卢敏俊[1] 

机构地区：[1]广州医学院第一附属医院急诊科

出　　处：《中国临床药理学与治疗学》2005年第7期787-790,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察阿司匹林对大鼠慢性压力负荷性心肌肥厚过程中炎症标记物及左室重构的影响。方法:采用腹主动脉缩窄致压力负荷性心肌肥厚大鼠模型,分为假手术组、手术组及阿司匹林组。术后20周用高频超声测定左心室结构和功能,心肌组织胶原Masson染色,测定总胶原容积百分比(CVF-T)和无冠状动脉小血管视野胶原容积百分比(CVF-NV)。ELISA法测定血清TNF-α、IL-6、IL-10、TGF-β和CRP水平。结果:手术组左室壁、室间隔增厚明显,左室重量增加,左室腔扩大,FS%下降。手术组TNF-αI、L-10在20周明显升高,但阿司匹林组较手术组下降;20周手术组CVF-T和CVF-NV明显增加,但阿司匹林组减少,与假手术组无差异。结论:炎症参与了压力负荷性心肌肥厚过程,阿司匹林可能有抗细胞因子作用并对心肌胶原的重塑有一定的影响。AIM： To investigate the influence of aspirin on rats with pressure overloaded hypertrophic myocardium and change of inflammation marker. METHODS： 17 male SD rats were randomly assigned to sham operated group （S, n = 5）, operated group （O, n = 7）, operated ＋ aspirin group （O-A, n = 5）. Hypertrophic myocardium was induced by gradually constricting the abdominal aorta in rats. After 16 weeks, O-A group was treated with aspirin（ 100 mg·kg^-1· d^-1 ）in drinking water for 4 weeks. All rats were determined the left ventricular （LV） structures and functions by echocardiography at 20 weeks after operation, respectively. Hearts were analyzed for determination the organ weight. Myocardial collagen was stained with Masson and CVF-T and CVF-NV were analyzed using a computer assisted procedure. Then, serum levels of TNF-α, IL-6, IL-10, TGF-β, CRP were measured by ELISA. RESULTS： Operated rats increased LV wall thickness, LV internal diameter, LV mass and had decreased FS%. In comparison to S group, TNF-α in O group increased at 20 weeks after operation, but that decreased in O-A group. Levels of IL-10 in O group were increased at 20 weeks. IL-10 in O-A group reduced compared with S group. CVF-T and CVF-NV was the greatest in O group and there was difference between O-A group and S group. CONCLUSION： Inflammation is involved in the development of myocardial hypertrophy. Aspirin has an influence on inflammation marker and may contribute to myocardial collagen remodeling in pressure overload model.

关 键 词：压力负荷 心肌肥厚 左室重构 阿司匹林 细胞因子 

分 类 号：R972[医药卫生—药品]