基于Z曲线的SARS冠状病毒特征的研究  

Study on Characteristics of SARS Coronavirus Based on Z Curve

作　　者：戴花[1] 邵世煌[1] 皋磊[1] 丁永生[1] 

机构地区：[1]东华大学信息科学与技术学院,上海200051

出　　处：《计算机仿真》2005年第7期252-256,共5页Computer Simulation

基　　金：国家自然科学基金青年基金(60004006);教育部高校博士点专项基金(20030255009)

摘　　要：刺突(Spike)蛋白是SARS(SevereAcuteRespiratorySyndrome)冠状病毒表面最重要的膜蛋白,它通过与被感染细胞的受体结合来作为感染的媒介。受此启发,该文利用Z曲线方法,对S蛋白及SARS受体序列进行探究,捕捉到一种SARS病毒的可视化特征。大量序列比对的结果证明该特征是SARS病毒所特有的。将这种特征图谱应用到SARS病毒的检测中,可以提供一种非标准的、简单、直观的检验方法,能够诊断一些利用标准方法难以判断的SARS病例。由此可见,Z曲线作为一种基因序列的几何学研究途径是一种有效的研究方法。Spike protein is the most important membrane protein on the surface of SARS （ Severe Acute Respiratory Syndrome） coronavirus. It associates with cellular receptors to mediate infection of their target cells. Inspired by this, this paper studies the genome sequences of S protein and SARS＇s receptor based on Z curve method. A kind of visualizing characteristics for SARS coronavirus is seized in this study. The results, derived from the comparisons among a large number of genome sequences, have proved that this kind of characteristics is special for SARS coronavirus. The characteristic maps can be used in the detection of SARS coronavirus to provide a nonstandard, simple and visualized detection approach, especially for the situation where the standard method＇s results are conflict. From this study, we have also viewed that Z curve initiates an effective way for analyzing gene sequences using a geometric approach.

关 键 词：冠状病毒 刺突蛋白 曲线 病毒特征图谱 

分 类 号：TP391[自动化与计算机技术—计算机应用技术] TP399[自动化与计算机技术—计算机科学与技术]