经导管封堵器介入治疗动脉导管未闭的临床研究  

The clinical study of transcatheter closure of patent ductus arteriosus with occluder device

作　　者：陈斌[1] 徐岩[1] 程自平[1] 许邦龙[1] 朱润硕[1] 

机构地区：[1]安徽医科大学第一附属医院心内科,安徽合肥230022

出　　处：《安徽医药》2005年第8期597-598,共2页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省教育厅自然科学基金资助课题(2003KJ195)

摘　　要：目的观察经导管封堵器治疗动脉导管未闭(PDA)的临床疗效.方法32例单纯PDA患者采用蘑菇伞动脉导管封堵器经皮经股静脉封堵治疗PDA,应用X线造影术观察即刻疗效,术后72 h、1个月、3个月分别行超声心动图评价治疗效果.结果X线主动脉造影测量PDA最窄处的直径平均6.8±1.1(3～12)mm,封堵器直径平均12.6±1.3(6～18)mm.全组技术成功率100%;术后10 min降主动脉造影显示29例无残余分流,3例存在极少量残余分流.术后肺动脉平均压较术前明显下降(P＜0.05).术中无任何严重并发症,3个月随访,未发现残余分流、封堵器移位、溶血、血栓或主、肺动脉狭窄.结论应用蘑菇伞动脉导管封堵器经导管介入治疗PDA安全有效,创伤小,成功率高,操作简单.Aim To evaluate the efficiency of transcatheter closure of patent ductus arteriosus （PDA） using occluder device. Methods 32 patients with PDA were treated with transcatheter closure with duct occluder device. Each PDA was occluded through the percutaneous procedure. Aortographies were made to evaluate the efficiency immediately after the procedure. Echocardiographies were performed 72 hours, 1 month and 3 months after the closure to find whether there was residual shunt or recanalization. Results The smallest diameter of PDA measured by aortography were 6.8±1.1 （3-12） mm, the mean diameter of duct occluder device measured by aortography were 12.6±1.3（6-18）mm. The technical successful rate was 100%. Aortography showed that 29 patients had been completely closed 10 minutes after operation, three patients had a trace shunt, the mean pressure of pulmonary artery declared significantly after operation （P〈0.05）. No complications happened during operation. Residual shunt, the place of duct occluder device, hemolysis, embolism and aortic stenosis didn＇t happen during 3 months follow-up. Conclusion Trans-catheter closure of PDA using duct occluder device is safe and efficient. The successful rate is high, and there is less trauma.

关 键 词：动脉导管未闭 介入治疗 封堵器 动脉导管未闭(PDA) 动脉导管封堵器 经导管介入治疗 临床研究 肺动脉平均压 X线造影术 技术成功率 

分 类 号：R541.1[医药卫生—心血管疾病]