抗菌药使用中药物治疗错误的研究  

A Study of Antimicrobial Medication Errors

作　　者：张亮[1] 王大猷[1] 迟丹怡[1] 李中东[1] 时颖华[1] 钟明康[1] 

机构地区：[1]复旦大学附属华山医院药剂科,上海200040

出　　处：《药物流行病学杂志》2005年第4期220-222,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:研究抗茵药使用中药物治疗错误(ME)的发生情况,探讨其防范重点。方法:药师深入中心 ICU病房,通过调查病历、直接观察的方式发现抗菌药ME。结果:10个月研究期间共发现ME301次,其中可预防药物不良事件(ADE)19次(3．3％),潜在ADE94次(16．2％)。有潜在危害ME(可预防的ADE+潜在ADE)中有生命威胁6次(5．3％),严重88次(77.9％),明显19次(16．8％)。结论:抗菌药使用中ME经常发生,其中约1／3 有潜在危害且往往带来严重后果,应该采取措施防范ME、特别是有潜在危害ME的发生。Objective： To study antimicrobial medication errors（ME） to find the prevention emphases. Method： Pharmacists participated daily in medical round in ICU wards, including reviewing patients＇charts and observing directly to identify their antimicrobial ME. Result： During 10 months of observation, 301 ME occurred, of which 19 （3.3%） were preventable adverse drug events （ADE） , and 94 （ 16.2% ） were potential ADE. Of all potential harmful ME （ preventable ADE ＋ potential ADE） , 6 （5.3%） were life threatening, 88 （77.9%） were serious, and 19 （ 16.8% ）were significant. Conclusion： The antimicrobial ME are common, and about one third is potentially harmful, which often leads some serious results. Some strategies are needed to reduce ME, especially the potentially harmful ones.

关 键 词：抗菌药 药物治疗错误 防范 重症监护病房 药物不良事件 

分 类 号：R978[医药卫生—药品]