2000-2004年我院4种抗癫痫药物血药浓度监测结果分析  

An Analysis of the Therapy Drug Monitoring Results of 4 Drugs from 2000 to 2004

作　　者：朱曼[1] 郭代红[1] 石莉[1] 宁静[1] 裴保香[1] 

机构地区：[1]解放军总医院药品保障中心第一临床药局,北京100853

出　　处：《药物流行病学杂志》2005年第4期223-225,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:通过对4种抗癫痫药血药浓度有效率和高于及低于有效浓度的百分率的统计分析,有针对性的指导临床,合理调整给药方案。方法:运用回顾性调查方法,对解放军总医院2000年1月-2004年12月所监测的4种抗癫痫药物的血药浓度结果进行分析。结果:4种药物的监测结果中,有效血药浓度范围内结果占年监测例次的百分率以卡马西平为最高,但总体上均较低;而低于有效浓度范围的结果在年监测例次中所占比例较大。结论:血药浓度监测结果是指导临床用药的依据之一,应综合分析患者的用药方案、用药史、实验室数据和临床疗效, 真正做到个体化给药。Objective： To monitor the blood drug concentrations to adjust the dosage for individual administration. Method ： The blood drug concentration results from 2000 to 2004 were analyzed with the retrospective method. Result ： The availability proportions of the 4 blood drug concentration results were low, and many points were dropped to the lower range of the effective blood concentration. Conclusion： We should attach importance to the therapy drug monitoring dosage, administration note, and laboratorial examination which are the bases to guide the clinical medication. This way we can adjust the dosage for individual administration.

关 键 词：治疗药物浓度监测 有效浓度范围 抗癫痫药 

分 类 号：R971.6[医药卫生—药品]