蜂胶对大鼠佐剂性关节炎的作用及其机制的研究  

Study on effects and mechanism of propolis on adjuvant arthritis in rats

作　　者：胡福良[1] 李英华[2] 朱威[1] 陈民利 应华忠 

机构地区：[1]浙江大学动物科学学院,浙江杭州310029 [2]浙江大学材料与化工学院,浙江杭州310027 [3]浙江中医学院,浙江杭州310053

出　　处：《中国药学杂志》2005年第15期1146-1148,共3页Chinese Pharmaceutical Journal

基　　金：浙江省重大科技攻关资助项目(2003C12021)

摘　　要：目的观察蜂胶液对佐剂性关节炎的作用及其机制。方法采用大鼠佐剂性关节炎模型进行观察比较蜂胶水提液和蜂胶醇提液的抗炎免疫作用。结果蜂胶醇提液和水提液均能够减轻局部组织的炎症反应,抑制足跖肿胀。通过测定大鼠关节炎渗出液中IFN-γ,IL-2,PGF2和IL-6含量,发现蜂胶液对IL-6和PGE2的产生有显著的抑制作用,而对IL-2和IFN-γ无明显影响。结论蜂胶具有良好的抗炎作用。OBJECTIVE To study the effects and the possible mechanism of propolis on adjuvant arthritis. METHODS The anti-inflammatory and immunization effects of propolis solutions extracted by ethanol （EEP） and water （WSD） through the arthritic rat model induced by Freund＇s adjuvant were investigated completely. RESULTS EEP and WSD showed an inhibiting fimction on edema induced by Freund＇s adjuvant complete and decreased the degree of local inflammatory response. EEP and WSD inhibited the increase of IL-6 and PGE2 content in inflammatory tissue fluid, but showed no significant influence on IL-2 and IFN-γ contents. CONCLUSION Propolismay may act on B lymphocyte system and inhibit the activation and differentiation of mononuclear-macrophage.

关 键 词：蜂胶 佐剂性关节炎 白细胞介素-6 前列腺素E2 

分 类 号：R285.6[医药卫生—中药学]