氯沙坦治疗特发性扩张型心肌病对心脏重塑的探讨  

Therapeutic effect of losartan on cardiac remodeling for patients with idiopathic dilated cardiomyopathy.

作　　者：欧阳荣超[1] 吴焱贤[1] 全屏寿[1] 余晋涛[1] 李崇虹[1] 胡允兆[1] 何宗云[1] 周艺[1] 

机构地区：[1]广东顺德第一人民医院,528300

出　　处：《中国实用内科杂志》2005年第8期712-714,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的探讨氯沙坦治疗特发性扩张型心肌病(IDCM)对心脏重塑及心功能改善的疗效.方法对1997-01～2002-12广东顺德第一人民医院IDCM住院病人56例次行超声心动图(UCG)检测.随机分两组:氯沙坦治疗组30例,在常规治疗的基础上加服氯沙坦50 mg/d及β-受体阻滞剂.常规治疗组26例,均用强心、利尿、补钾、血管扩张剂,每月随访1次,共6个月,分别统计第3个月及第6个月时UCG结果.结果氯沙坦治疗组,从第3个月起,UCG各指标比治疗前均有显著改善(P<0.05);6个月时改善更明显(P<0.01).常规治疗组亦有不同程度改善,但无统计学意义(P>0.05).结论氯沙坦治疗IDCM,3个月就能有效地抑制心肌重塑、降低心脏重量、改善心功能;持续用药6个月,改善程度更加明显.Objective To assess the therapeutic effect of losartan on cardiac remodeling for patients with idiopathic dilated cardiomyopathy （IDCM）. Methods From Jan. 1997 to Dec. 2002, UCG was performed in 56 patients with IDCM. They were divided into two groups. The first group of 30 patients were treated with losartan （50mg） plus βreceptor blocker per day. The other group of 26 patients received standard conventional therapy, including cardiac, diuretic and potassium- spring. All patients were interviewed once a month for the following 6 months. The results of UCG were based on the examination taken by the end of 3 months and 6 months. Results In the first group, UCG improved significantly （ P 〈0.05） after 3 months and more obvious （ P 〈0.01） after 6 months. In the second group, UCG improved only slightly but not significantly （P〉0.05）. Conclusion Losartan may be effective to restrict the heart reconstruction and reduce the heart weigh and improve the heart function after 3 - month therapy and may be more effective after 6 months of therapy.

关 键 词：心肌病扩张型 肾素-血管紧张素-系统 氯沙坦 

分 类 号：R5[医药卫生—内科学]