甲状腺功能亢进症患者骨密度测定的临床研究  

Study of bone mineral density in patients with hyperthyroidism

作　　者：高凌[1] 

机构地区：[1]湖北省襄樊市中心医院内分泌科

出　　处：《华中医学杂志》2005年第4期243-244,共2页Central China Medical Journal

摘　　要：目的探讨甲状腺功能亢进症患者骨密度的改变情况。方法应用定量超声法测定150例甲状腺功能亢进症患者右足跟骨的骨超声振幅衰减(BUA)和超声传导速度(SOS),并以150例性别、年龄、体重、身高和体重指数与甲亢组相匹配的健康者作为对照组,据此统计分析甲亢组的骨量减少及骨质疏松的发生率。结果甲状腺功能亢进症组的BUA和SOS均明显降低,与对照组比较,差异有极显著性(P<0.01);甲亢组总的骨质丢失发生率为44.0%,对照组为11.3%,两组差异有极显著性(P<0.01),其中,甲亢组骨质疏松的发生率为18.7%,对照组为3.3%,两组差异有极显著性(P<0.01)。结论甲状腺功能亢进症患者的骨密度明显降低,骨量减少,骨质疏松发病率明显增高。Objective To investigate the changes of bone mineral density （BMD） in patients with hyperthyroidism. Methods Broadband Ultrasound attenuation（BUA） and the speed of sound （SOS） of right calcaneus were measured in 150 patients with hyperthyroidism and 150 normal controls using quantitative ultrasound（QUS）. Incidence of osteopenia and osteoporosis were analyzed accordingly. Results BUA and SOS were lower in all patients with hyperthyroidism than in controls （P〈0. 01 ）.Incidence of bone mineral density diminution as higher in patients with hyperthyroidism than in controls （44. 0% vs 11.3%,P〈0. 01）. Incidence of osteoporosis （OP） was higher in patients with hyperthyroidism than in controls （18. 7% vs 3. 3%, P〈0. 01）. Condusion In patients with hyperthyroidism, BMD is decreased, and incidence of OP is increased significantly.

关 键 词：甲状腺功能亢进症 骨密度 骨质疏松 骨密度测定 患者 临床研究 超声振幅衰减 体重指数 骨量减少 定量超声法 

分 类 号：R581.1[医药卫生—内分泌] R681[医药卫生—内科学]