细胞间黏附分子-1基因469K/E多态性与老年冠心病  

469K/E polymorphism of the ICAM-1 gene and the elderly with coronary heart disease

作　　者：商青[1] 路方红[1] 温培娥[1] 苏国海[2] 吴凡[1] 赵颖馨[1] 田奇[3] 

机构地区：[1]山东省医学科学院基础医学研究所,山东济南250062 [2]济南市中心医院心内科,山东济南250013 [3]香港中文大学威尔斯亲王医院麻醉及深切治疗系

出　　处：《中华老年心脑血管病杂志》2005年第2期103-105,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：山东省医学科学院资助 (2 0 0 4 0 0 5 )

摘　　要：目的　探讨细胞间黏附分子 1(intercellularadhesionmolecule -1,ICAM- 1)基因4 6 9K/E多态性与老年冠心病患者的关系。方法　利用巢式聚合酶链反应技术,检测12 2例老年冠心病患者(冠心病组)和117例非冠心病住院患者(对照组)的4 6 9K/E突变基因型。结果　基因型频率符合Hardy Weinberg平衡;冠心病组KK +KE基因型频率明显高于EE型,与对照组有显著性差异(P =0 .0 11) ;二元logistic回归显示,K等位基因、吸烟增加了冠心病发病的危险,K等位基因与吸烟对冠心病的发生具有协同作用。结论　ICAM 1基因4 6 9K/E多态性与老年冠心病的发病有关。Objective To observe the relationship between intercellular adhesion molecule -1 （ICAM-1 ） gene 469K/E polymorphism and CHD in the elderly. Methods 122 controls and 117 patients with CHD were enrolled. All patients and controls were genotyped by polymerase chain reaction and allele-specific oligonucle-otide techniques （nested PCR） for the ICAM-1 polymorphism. Results Genotype distribution was in accordance with Hardy-Weinberg equilibrium. The frequency of （KK ＋ KE） genotype was much higher than that of EE in CHD, which had significant difference with the control （ P = 0.011 ）. By means of binary logistic regression analysis, it was found that K genotype and smoking enhanced the risk of CHD, and that there was a synergistic action between K genotype and smoking which can influence the risk of CHD. Conclusions ICAM-1 gene 469K/E polymorphism has a relationship with CHD in the elderly, and K genotype may be one of the genetic factors influencing the risk of CHD.

关 键 词：冠状动脉疾病 胞间粘附分子1 基因 聚合酶链反应 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]