雷公藤双层片制备工艺优选  

Optimization for Preparation of Double-deck Tablets of Radix Tripterygjun Wilfordii

作　　者：聂诗明[1] 柏传明[2] 

机构地区：[1]湖北中医学院药学院,湖北武汉430061 [2]湖北省中医药研究院,湖北武汉430074

出　　处：《中国药业》2005年第8期45-46,共2页China Pharmaceuticals

摘　　要：目的:以丙烯酸树脂Ⅱ为主要材料,优选雷公藤双层片的制备工艺。方法:分别对双层片速释部分、缓释部分辅料进行筛选,通过正交设计试验,以体外溶出度测定优化处方和工艺。结果:雷公藤双层片优选的制备工艺条件为速释部分以淀粉及CaCO3为辅料、羟丙基纤维素(HPC)为黏合剂制备,缓释部分以聚乙二醇6000(PEG6000)、糊精、丙烯酸树脂Ⅱ制备,缓释与速释层药物比例为7∶3,丙烯酸树脂用量10%,制片压力3～5kg/cm2等。制备的雷公藤双层片具良好的缓释性能,在2,5,10h药物释放分别达到20%～40%,40%～65%,75%以上。结论:优选的工艺条件适合于雷公藤双层片的制备。Objective： To study the preparation procedure of the Radix Tripterygjun Wilfordii double-deck tablets, and Eudragit L Ⅱ was prepared as the main material. Methods： The orthogonal design was applied to optimize the prescription and preparation formulation with respect to the release rate by selecting the excipients of rapid- release part and slow-release part. Results： The tablets with starch and CaCO3 as exeipients and HPC as adhesives were prepared rapid- release part. The dispersoid which was made up of PEG 6000, dextrin, Eudragit L H was further manufactured into tablets which were applied to prepared slow-release part. The proportion of the drug was 7：3 in the decks of rapid-release and slow- release. The additive of Eudragit L Ⅱ was 10%. The press of preparation was 3-5 kg/cm^2. The slow-release ability of Radix Tripterygjun Wilfordii double-deck tablets was good. The release rate reached 20% -40% ,40% -60%, above 70%, at 2 h, 5 h and 10 h, respectively. Conclusion： The optimized factors were applicable to prepare the product.

关 键 词：雷公藤 双层片 制备工艺 缓释 正交设计 

分 类 号：TQ460.6[化学工程—制药化工] R944.4[医药卫生—药剂学]