产前应激对脑海马神经干细胞增殖与分化的影响  

Effect of prenatal stress on the proliferation and differentiation of neural stem cell in hippocampus

作　　者：李晖[1] 朱忠良[2] 宋天保[3] 

机构地区：[1]西安交通大学第一附属医院儿科,陕西省西安市710061 [2]西安交通大学医学院生理教研室,陕西省西安市710061 [3]西安交通大学医学院组胚教研室,陕西省西安市710061

出　　处：《中国临床康复》2005年第26期189-191,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:急、慢性应激能明显抑制本代大鼠脑海马神经干细胞的增殖分化,产前应激对子代神经干细胞会产生何种影响?了解神经干细胞在中枢神经系统内的分布特征及其分化,对脑海马神经干细胞在产前应激相关行为中的调节作用进行阐述。资料来源:应用计算机检索Medline1990-01/2002-01与神经干细胞和应激相关的文章,检索词“Neuralstemcell,Stress”为检索词,从1990-01/2004-12网址为http://lib.tsinghua.edu.cn/数据库中检索与神经干细胞和应激相关的文章,限定文章语言种类为中文,检索词“神经干细胞,应激”。资料选择:对资料进行初审,选取包括处理组和对照组的文献,筛除明显不随机的研究,对剩余的文献开始查找全文。纳入标准为①随机对照研究。②实验或临床研究包含平行对照组。③前后对照试验研究。排除标准:重复性研究及综述类文章。资料提炼:共收集到415篇关于神经干细胞与脑海马应激损伤的随机和未随机的文章。26个实验或临床研究符合纳入标准。排除的389篇中301篇为未随机实验或重复性研究,88篇为综述类文章。资料综合:纳入的26个实验包括511例患者和625只实验动物。说明了脑海马齿状回是成年哺乳动物不断产生新神经元的脑区之一,这些新神经元具有修复脑海马损伤的作用,但成年动物神经干细胞持续增殖的生理作用并不清楚。脑海马齿状回神经干细胞的分化调控受多种内外环境因素的影响,产前应激可引起子代脑海马神经元及神经元超微结构的损伤,其损伤效应可能与产前应激引起的氧化物生成增加有关。结论:产前应激能调节脑海马神经干细胞的增殖与分化,提示神经干细胞可能参与脑功能调节和动物行为活动。将易培养的干细胞转入胎儿体内,通过一定的条件诱导其分化生成神经细胞修补脑海马损伤,对预防和治疗产前应激所致子代脑损伤�OBJECTIVE： Acute and chronic stress can obviously inhibit the proliferation and differentiation of neural stem cells in hippocampus of the rats of the primary generation. What is the effect of prenatal stress on neural stem cells of the second-generation rats？ To understand the distribution and differentiation of neural stem cells （NSCs） in central nervous system of adult rats ,the regulation role of hippocampal NSCs in interrelated behavor of stress are documented. DATA SOURCES： The relevant articles to NSCs and stress from January 1990 to January 2002 were searched for in Mediline by inputting the key words “Neural stem cell,Stress”.The relevant articles to NSCs and stress from January 1990 to December 2004 were searched on line http：//lib.tsinghua.edu.cn in English with the key words of “Neural stem cell, stress”. STUDY SELECTION： Having been looked through primarily, the references in the treatment group and control group were selected, and the obviously non-randomized studies were excluded and the other literatures were searched for the whole papers. Inclusion criteria： ① randomized controlled study. ② Experiment and clinical study include parallel control group . ③ Before-after control experimental study. Exclusion criteria： Repetitive study and reviewed articles DATA EXTRACTION： A total of 415 random and non-random relevant literatures about NSCs and stress injury in hippocampus were collected. Twenty-six experiments or clinical studies were accorded with the inclusion criteria. Totally 301 among the excluded 389 were random experiment or repetitive study and 88 were reviewed papers. DATA SYNTHESIS： The involved 26 experiments include 511 patients and 625 experimental animals indicating hippocampus dentate gyrus（DG） is one of brain subregions of producing new neurons continuously in the adult mammal. The new neurons have a role of renovating the damage in hippocampus, but the physiology effect of continuing proliferation of neural stem cells was not clear. NSCs in hi

关 键 词：应激 干细胞 脂质过氧化作用 综述文献 神经干细胞增殖 慢性应激 鼠脑海马 增殖分化 产前 神经元超微结构 

分 类 号：R338[医药卫生—人体生理学] R363.27[医药卫生—基础医学]