组织细胞移植治疗中枢性瘫痪的实验与临床  

Experiment and clinic of histocyte transplantation in the treatment of central paralysis

作　　者：潘力雄[1] 刘运生[2] 

机构地区：[1]东莞市人民医院神经外科,广东省东莞市523018 [2]中南大学湘雅医院神经外科,湖南省长沙市410008

出　　处：《中国临床康复》2005年第26期191-193,共3页Chinese Journal of Clinical Rehabilitation

基　　金：广东省卫生厅科研课题立项(A846)~~

摘　　要：目的:探讨中枢神经系统损伤所致瘫痪的治疗现状和进展水平。资料来源:计算机检索Medline2000-01/2005-01与中枢性瘫痪相关文章,检索词“Centralnervousinjury,paralysis,celltransplantation,therapy”,限定文章语言种类为英文。光盘检索中国生物医学文献数据库2000-01/2005-01期间的相关文章,限定文章语言种类为中文,检索词“瘫痪、治疗”。资料选择:对资料进行初审,选取有关中枢神经系统损伤所致瘫痪的临床和/或实验研究的文献,包括中西医治疗的各种措施,特别是国外有关神经干细胞移植治疗的最新进展。资料提炼:共收集有关的随机与非随机临床和/或实验的研究300余篇,其中密切相关的40余篇。资料综合:①研究中西结合的临床康复是目前国内常用的治疗方法,但缺乏严格的随机对照。②国外文献报道表明仅靠促进内在神经再生和消除外在抑制因素难以解决中枢神经系统损伤后的再生与功能恢复问题。③神经干细胞移植是目前的研究热点。胚胎组织来源的神经干细胞移植涉及伦理道德、免疫排斥反应等一系列问题,因此只能限于动物实验研究。成体非神经组织来源的神经干细胞包括自体骨髓基质细胞移植为中枢性瘫痪的治疗带来了新的希望。结论:脑和脊髓组织有自我修复的潜能,但临床常用的康复方法和中西药治疗收效甚微,而细胞移植将有可能成为中枢性瘫痪较理想的治疗方法之一。OBJECTIVE： To explore the therapeutic actuality and progressive level of paralysis induced by central nervous system injury. DATA SOURCES： We searched Medline for the articles about central paralysis published from January 2000 to January 2005 with the keywords “Central nervous injury, paralysis, cell transplantation, therapy”and limited the language to English. CBMdisc was searched by optical disk for the relative articles published from January 2000 to January 2005 with the language limited to Chinese and the keywords “paralysis, therapy”： STUDY SELECTION： The materials were selected firstly; literatures about the clinical and/or ,experimental research of paralysis induced by central nervous system injury were selected, including various kinds of measure of Chinese and Western therapy, especially the latest development of nervous stem cell transplantation overseas. DATA EXTRACTION： Over 300 articles about random and non-random clinical and/or experimental researches were collected, among them more than 40 closely relative articles. DATA SYNTHESIS： ① The research on clinical rehabilitation combined with Chinese and Western medicine was the common therapeutic method internal at present, but lacked of serious random control. ② The overseas literature reports indicated that it was difficult to solve the regeneration and functional recovery problems after the injury of central nervous system by the acceleration of internal regeneration of nerve and precluding external inhibitive factors, ③ The nervous stem cell transplantation was the hot research at present, The nervous stem cell transplantation which was the origin of embryonic tissue involved in a series of problems like ethics morality and immunological rejection etc., therefore, could only limited to animal＇s experimental research. The nervous stem cell transplantation which was the origin of adult non-nerve tissue included autologous bone marrow stroma cell transplantation which brought new hope for the therapy of central paralysis.

关 键 词：中枢神经系统/损伤 麻痹 功能恢复 细胞移植 神经干细胞移植治疗 动物实验研究 中枢性瘫痪 临床康复 组织来源 中国生物医学文献数据库 

分 类 号：R457.7[医药卫生—治疗学] R285.5[医药卫生—临床医学]