川芎嗪联合苦参素治疗慢性乙肝临床观察  

The clinical study of ligustrazine in combination with oxymatrine for the treatment of chronic hepatitis B

作　　者：赵淑芳[1] 贾继珍[1] 汪雪琪[1] 岳亚敏[1] 

机构地区：[1]鹤壁煤业集团总医院,河南鹤壁458000

出　　处：《临床肝胆病杂志》2005年第4期211-212,共2页Journal of Clinical Hepatology

摘　　要：观察川芎嗪联合苦参秦治疗慢性乙肝的疗效。86例患者随机分为两组,对照组(B组)36例给苦参素及常规护肝药;治疗组(A组)50例在对照组基础上联用川芎嗪(40-80)mg/日,静脉滴注,疗程均为4周。结果:治疗4周后,治疗组ALT及TBil复常率分别为92%、96%,对照组分别为55.5%,77.7%,两组间有显著性差异(P< 0.05),HBV DNA及HBeAg阴转率略高于对照组,但无统计学差异。川芎嗪联合苦参素明显改善肝功能且抑制DNA 复制,是治疗慢性乙肝的有效联合。to observe the efficacy of chronic hepatitis B with ligustrazine and oxyrnatrine, 86 cases were randomly divided into the test group and the control group, the control group （36 cases） was treated with oxymatrine and common liver protecting medicines, the test group （50 cases） was treated ＇also with the same drags but adding ligustrazine （60 - 80mg）/d by intravenous drip for 4 weeks. 4 weeks later, ALT recovery rate and TBil recovery rate of the test group were 92% and 96 %, while control group were 55.7% and 77.7% respectively, the difference was significantly （ P 〈 0.05）. the HBV DNA and the HBeAg serocoversion rate in test group was slightly higher than that of control group. The paper indicated the treatment of chronic hepatictis B with ligustrazine and oxymatrine is more effective than with only oxymatrine.

关 键 词：慢性乙肝 川芎嗪 苦参素 

分 类 号：R259[医药卫生—中西医结合]