抗微生物药物PK-PD研究在优化兽药给药方案中的应用  

Pharmacokinetic-pharmacodynamic relationships of antimicrobial drugs in acquirring optimal regimen of veterinary medicine

作　　者：高延玲[1] 陈杖榴[1] 王付民[1] 

机构地区：[1]华南农业大学广东省兽药研制与安全评价重点实验室,广东广州510642

出　　处：《中国兽药杂志》2005年第8期27-31,共5页Chinese Journal of Veterinary Drug

摘　　要：PKPD模型可用于优化兽药给药方案,制订合理的给药间隔和剂量,在减少细菌耐药性方面有重要意义。本文综述了β内酰胺类、氨基糖苷类、氟喹诺酮类、大环内酯类等抗微生物药物的PKPD研究现状,以期为兽药厂家在药物开发、设计合理的剂型与给药方案方面提供依据。The studies of pharmacokinetic-pharmacodynamics integration have important value on the design of antimicrobial regimen, thus directing rational adminstration and avoiding drug resistance. This review is mainly about PK-PD researches on beta lactams, aminoglycosides, fluoroquinolones, macrolides, etc. Hopefully it will be helpful for veterinary companies in developing new drugs and acquiring optimal regimen.

关 键 词：药代动力学 药效动力学 优化给药方案 减少细菌耐药性 

分 类 号：S859.796[农业科学—临床兽医学]