四组复方中药对模拟失重大鼠血液流变性的影响  

Effect of Four Chinese Herb Decoctions on Hemorheology in Rats under Simulated Weightlessness

作　　者：董颀[1] 沈羡云[2] 孟京瑞[2] 张淑静[2] 汪德生[2] 杨光华[2] 

机构地区：[1]广州医学院生理教研室,邮政编码广州510182 [2]航天医学工程研究所

出　　处：《微循环学杂志》2005年第3期41-43,F0006,F0009,共5页Chinese Journal of Microcirculation

基　　金：国家863计划资助项目(863-2-3-2-4)

摘　　要：目的:观察中药在对抗失重或模拟失重导致的血液循环状态紊乱中的作用。方法:采用大鼠头低位30°尾吊模型模拟失重对机体的影响,用四组(丹黄刺组、参川熟组、参山杜组、参银生组)复方中药对抗模拟失重大鼠血液流变学变化。结果:单纯尾吊导致大鼠体重明显降低(P<0.01),中、低切血粘度、纤维蛋白原含量、异形红细胞比例明显增高(P<0.01);红细胞最大变形指数、积分变形指数和血细胞压积明显降低(P<0.01)。中药组与单纯尾吊组相比,各指标均有不同程度地改善。结论:复方中药可有效改善尾吊导致的大鼠血液流变学异常。Objective： To investigate the role of Chinese herb medicine on improving the blood circulation under simulated weightlessness. Method： Head down tilts -30°（HDT）rnodel was used to simulate the effect of weightlessness on rats, and four groups of Chinese herb decoctions were used to counter hemorheological changes due to simulated weightlessness. Results： After 30 days-HDT, the body weight of rats decreased distinctly（ P 〈 0.01 ）, the blood viscosity in low and middle shear, plasma fibrinogen and the rate of erythrocytes with abnormal shape increased significantly（P〈 0.01 ）,and erythrocyte deformability（DImax, IDI ） and hernatocrit（HCT） decreased remarkly（ P 〈 0.01 ）. Chinese herb medicine were able to meliorate the hemorheological changes caused by simulated weightlessness. Conclusion： It is suggested that Chinese herb medicine are effective to improve hemorheological abnorrnity under simulated weightlessness.

关 键 词：大鼠血液流变性 模拟失重 中药对 血流动力学变化 复方 微重力环境 血液学改变 血液流变学 低动力状态 

分 类 号：R277.733[医药卫生—中医学] R852.22