Synthesis of the Biomimetic Polymer: Aliphatic Diamine and RGDS Modified Poly(d,l-lactic acid)  

作　　者：Xu Feng NIU Yuan Liang WANG Yan Feng LUO Jun PAN Li Xia GUO 

机构地区：[1]Key Lab of Biomechanics ＆ Tissue Engineering （Chongqing University）, Ministry of Education Bioengineering College of Chongqing University, Chongqing 400044

出　　处：《Chinese Chemical Letters》2005年第8期1035-1038,共4页中国化学快报（英文版）

基　　金：This study was supported by the National Natural Science Foundation of China(No.30270395 and 30300084);the National"863"Project(No.2003AA32X210).

摘　　要：A novel poly（d, /-lactic acid） （PDLLA） based biomimetic polymer was synthesized by grafting maleic anhydride, butanediamine and arg-gly-asp-ser （RGDS） peptides onto the backbone of PDLLA, aiming to overcome the acidity and auto-accelerating degradation of PDLLA during degradation and to improve its biospecificity and biocompatibility. The synthetic copolymer was characterized by FTIR, ^13C NMR and amino acid analyzer （AAA）.A novel poly（d, /-lactic acid） （PDLLA） based biomimetic polymer was synthesized by grafting maleic anhydride, butanediamine and arg-gly-asp-ser （RGDS） peptides onto the backbone of PDLLA, aiming to overcome the acidity and auto-accelerating degradation of PDLLA during degradation and to improve its biospecificity and biocompatibility. The synthetic copolymer was characterized by FTIR, ^13C NMR and amino acid analyzer （AAA）.

关 键 词：Poly（d l-lactic acid） maleic anhydride butanediamine arg-gly-asp-ser modification. 

分 类 号：O632[理学—高分子化学]