Three New Anthraquinones from Polygonum cillinerve  

作　　者：Huan Yang QI Chao Feng ZHANG Mian ZHANG Jian Qun LIU Zheng Tao WANG 

机构地区：[1]Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038

出　　处：《Chinese Chemical Letters》2005年第8期1050-1052,共3页中国化学快报（英文版）

摘　　要：Three new anthraquinones, emodin-8-β-D-（2＂-O-coumarate）glucoside 1, emodin-8-β-D-（6＇-O-acetyl）glucoside 2 and physicon-8-β-D-（6＇-O-acetyl）glucoside 3, were isolated from the roots of Polygonum cillinerve and their structures were established by spectroscopic methods. The biological activity indicated that compound 1 had the scavenging activity on 1,1-diphenyl-2-picrylhydrazyl （DPPH） radicals （the IC50 = 8.5 μmol/L）, and compound 1-3 showed no activities against HL-60 and BCJC-823 cells by MTT method in vitro.Three new anthraquinones, emodin-8-β-D-（2＂-O-coumarate）glucoside 1, emodin-8-β-D-（6＇-O-acetyl）glucoside 2 and physicon-8-β-D-（6＇-O-acetyl）glucoside 3, were isolated from the roots of Polygonum cillinerve and their structures were established by spectroscopic methods. The biological activity indicated that compound 1 had the scavenging activity on 1,1-diphenyl-2-picrylhydrazyl （DPPH） radicals （the IC50 = 8.5 μmol/L）, and compound 1-3 showed no activities against HL-60 and BCJC-823 cells by MTT method in vitro.

关 键 词：Polygonum cillinerve ANTHRAQUINONE antioxidant activity cytotoxic activity. 

分 类 号：O629.1[理学—有机化学]