脂必妥胶囊与辛伐他汀调节血脂代谢疗效比较  

Comparison of effects between zhibituo and simvastatin in treating hyperlipemia

作　　者：刘甲兴[1] 芮磊[1] 

机构地区：[1]解放军第180医院心内科,福建泉州市362000

出　　处：《心血管康复医学杂志》2005年第4期353-355,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:比较脂必妥胶囊与辛伐他汀片调节血脂代谢的疗效。方法:原发性血脂代谢紊乱患者68例随机被分为脂必妥治疗组(35例,男20例,女15例,平均年龄58±12岁)和辛伐他汀对照组(33例,男20例,女13例,平均年龄56±11岁),脂必妥组早、晚口服脂必妥胶囊各0. 24 g,辛伐他汀组每晚口服辛伐他汀片20 mg,疗程均为8 周。结果:脂必妥组使TC、LDL-C、TG 分别降低32. 5%、39. 2%和21%,HDL-C 升高5. 7%,而辛伐他汀组分别为38. 7%、42. 7%、30. 2%和8. 1%(P<0. 05～<0. 01) ,两组无显著差异(P>0. 05) 。脂必妥调节TC、TG、HDL- C、TC-HDL/HDL 的有效率分别为90. 4%、59. 4%、55. 2%、92. 7%,而辛伐他汀组分别为91. 4%、67. 3%、44. 5%、93. 4%,两组无显著差异(P>0. 05) 。结论:早晚口服脂必妥胶囊各0. 24 g 与每晚口服辛伐他汀片20 mg 调节血脂代谢紊乱的效果相同。Objective： To compare the effect of zhibituo and simvastation in treating hyperlipemia. Methods： A total of 35 patients with hyperlipemia were treated with zhibituo 1 capsule （0.24 g）, 2 times/d for 8 weeks. Other 33 patients received simvastatin 20 mg every night for 8 weeks. Results： Both drugs were equally effective in decreasing TC, LDL-C, TG and increasing HDL-C （P〉0.05）. The TC. LDL-C. TG respectively decreased 32.5%, 39.2%,21%, but HDL-C increased 5.7% in zhibituo group. The TC, LDL-C, TG, respectively decreased 38.7%, 42.7%,30.2%, but HDL-C increased 8.1% in simvastatin group. The effective power of TC, TG, HDL-C, TC-HDL/HDL respectively was 90. 4%, 59.4 %, 55.20%, 92. 7% in zhibituo group, and 91.4 %, 67.3%, 44.5%, 93.4% in simvastatin group, which had no significant difference between two groups （P〉0. 05）. Adverse reaction of two groups are all mild. Conclusion： Zhibituo is an effective and safe drug in treating hyperlipidemia as well as simvastatin.

关 键 词：脂必妥 辛伐他汀 高脂血症 

分 类 号：R541.75[医药卫生—心血管疾病]