红毛五加多糖对四氯化碳肝损伤大鼠的保护作用  

Protective action of Acanthopanax giraldii Harms polysaccharides on CCl_4 induced liver injury in rats

作　　者：鞠洋[1] 骆勤[1] 党月兰[2] 

机构地区：[1]兰州医学院第二附属医院药剂科,兰州730030 [2]兰州医学院药理学教研室,兰州730000

出　　处：《中药药理与临床》2005年第3期25-26,共2页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:研究红毛五加多糖(AGP)对四氯化碳(CCl4)肝损伤的保护作用。方法:大鼠CCl4肝损伤模型进行实验。结果:AGP能明显抑制CCl4肝损伤大鼠血清AST、ALP、BILIT和肝TG水平的升高及血清TP、TG、TC、Alb和Glu水平的下降;同时使血清升高的NO含量降低。结论:AGP对CCl4肝损伤大鼠有明显保护作用,其机制可能与降低过高的NO含量有关。Objective： To study the protective action of Acanthopanax giraldii Harms polysaccharides （AGP） on CCl4 induced liver injury in rats. Methods： The injured liver model induced by injection CCl4 in rats. Results： AGP inhibited the rise of serum aspartate aminotransferase （AST）, alkaline phosphatase（ALP）, total bilirubin（BILIT）, hepatic triglycerldes（TG） and nitric oxide（NO）. It also inhibited the reduction of serum total protein（TP）, albumin（Alb）, total cholesterol（TC）, TG and blood sugar（Glu） in CCh-intoxicated rats. Conclusion： AGP possess protective action on CCl4 induced liver injury in rats. The mechanism of AGP working is related to the reduction of ,serum NO.

关 键 词：红毛五加多糖 CCL4肝损伤 天门冬氨酸氨基转移酶 甘油三酯 总蛋白 一氧化氮 四氯化碳肝损伤 保护作用 大鼠 CCL4肝损伤 

分 类 号：R285.5[医药卫生—中药学]