手性选择剂萃取分离特布他林对映体  

Extraction and Separation of Terbutaline Enantiomorph with a Chiral Selector

作　　者：焦飞鹏[1] 黄可龙[1] 彭霞辉[1] 于金刚[1] 赵学辉[1] 李晓刚[1] 

机构地区：[1]中南大学化学化工学院,长沙410083

出　　处：《应用化学》2005年第8期818-822,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20376085);湖南省自然科学基金(03JJY3020)资助项目

摘　　要：研究了特布他林对映体在含手性选择剂(L-酒石酸己酯)水-有机溶剂两相体系中的萃取分配行为。考察了有机溶剂、亲脂性阴离子和pH值对分配系数和分离因子的影响。实验表明,BPh4-与特布他林对映体形成2种疏水性复合盐,促进对映体在有机溶剂中的溶解。所考察的2类有机溶剂的萃取性能存在差异,以正庚烷为有机溶剂较合适。水相pH值对萃取性能也有显著影响。基于实验已确定的萃取条件,采用液膜逆流萃取技术分离特布他林对映体。为证明该系统的可行性,进行了传质性能实验,产品光学纯度可达99%。Distribution behavior of terbutaline enantiomorph was investigated in a aqueous/organic two-phase system containing a chiral selector（L-dihexyltartrate）. The influences of organic solvents, lipophilic anions and pH value on the distribution coefficient（k） and the separation factor（α） were investigated. The results show that tetraphenylborate lipophilic anion and terbutaline enantiomorph form two lipophilic salt complexes, which facilitates the solubilization of the enantiomorph in the organic phase. The extraction performance of the two kinds of organic solvent is different, and n-heptane is a better organic solvent. However, pH value of the aqueous phase also influences the extraction performance obviously. Under the determined extraction conditions, a new process of countercurrent liquid membrane extraction technology was adopted to separate terbutaline enantiomorph. To demonstrate the feasibility of the system, mass transfer experiments were performed, in which terbutaline enantiomorph of 99% optical purity can be obtained.

关 键 词：特布他林对映体 手性选择剂萃取 中空纤维 膜分离 

分 类 号：O652.6[理学—分析化学]