含氯羧酸吡唑醛肟酯化合物的合成及生物活性  

Synthesis and Biological Activity of Carboxylic Pyrazolyl Oxime Esters Containing Chlorine

作　　者：杨丽敏[1] 华水波[1] 刘钊杰[1] 

机构地区：[1]华中师范大学化学学院

出　　处：《应用化学》2005年第8期829-834,共6页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20102001)资助项目

摘　　要：从1-苯基-3-甲基-吡唑-5-酮出发,通过与Vismeier(DMF/POCl3)试剂反应得到1-苯基-3-甲基-5-氯-吡唑-4-甲醛(2),将其与羟胺肟化,再与相应的取代酰氯进行醇解反应,合成了17种未见报道的含氯羧酸吡唑醛肟酯类化合物,这些化合物的结构均经过1HNMR、IR、元素分析测试技术的证实,部分化合物还经过了EI-MS或LC/MS/MS测试技术的确证。初步生物活性测试结果证明,部分化合物具有较好的除草、杀菌、杀虫活性。Seventeen new carboxylic pyrazolyl oxime esters containing chlorine were prepared. Their structures were confirmed by virtue of ^1H NMR, IR and elemental analysis. Some of them were also confirmed by means of EI-Ms or LC/MS/MS. The preliminary bioassay for these compounds showed that some of them displayed good herbicidal and pesficidal as well as fungicidal activities.

关 键 词：羧酸吡唑醛肟酯 合成 生物活性 

分 类 号：O626[理学—有机化学]