多壁碳纳米管修饰玻碳电极测定乙炔雌二醇  

Voltammetric Determination of Ethynylestradiol Using Multi-wall Carbon Nanotube Modified Glassy Carbon Electrode

作　　者：张升晖[1] 胡胜水[2] 

机构地区：[1]湖北民族学院化学化工学院,恩施445000 [2]武汉大学化学与分子科学学院

出　　处：《应用化学》2005年第8期857-860,共4页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(60171023);湖北省教育厅自然科学基金(2002008010)资助项目

摘　　要：基于多壁碳纳米管对乙炔雌二醇的催化能力,建立了直接测定乙炔雌二醇的电分析方法. 多壁碳纳米管所具备的奇特性质使得乙炔雌二醇的氧化峰电流显著提高,同时氧化过电位降低,测定的灵敏度大为提高. 此法测定乙炔雌二醇的线性范围为1×10-7～4×10-5 mol/L,开路富集3 min后检测限为3×10-8 mol/L. 对于1×10-6 mol/L的乙炔雌二醇平行测定10次的相对标准偏差为6.2%. 该方法已用于乙炔雌二醇片剂中乙炔雌二醇含量的测定.An electrochemical method was developed for the determination of ethynylestradiol based on the electrocatalytic activity of multi-wall carbon nanotube （MWNT）. Owing to the unique and extraordinary properties of MWNT, the oxidation peak current of ethynylestradiol increases remarkably on a MWNT-modified glassy carbon electrode （ GCE）, accompanied by the lowering of oxidation overpotential. The oxidation peak current varies linearly with the concentration of ethynylestradiol in the range from 1×10^-7 to 4×10^-5 mol/L. The detection limit is 3×10^-8mol/L after open-circuit accumulation for 3 min. The relative standard deviation（RSD） of ten measurements is 6.2% for 1×10^-6 mol/L ethynylestradiol, indicating the good reproducibility. This proposed method was successfully employed in detecting ethynylestradiol in ethynylestradiol tablets.

关 键 词：多壁碳纳米管 乙炔雌二醇 化学修饰电极 电化学测定 

分 类 号：O657.1[理学—分析化学]