过氧化氢存在下平行催化氢波法测定奥沙普秦  

Polarographic determination of oxaprozin using its parallel catalytic hydrogen wave in the presence of hydrogen peroxide

作　　者：马淮凌[1] 徐茂田[1] 宋俊峰[2] 

机构地区：[1]商丘师范学院化学系,河南商丘476000 [2]西北大学陕西省电分析化学重点实验室,陕西西安710069

出　　处：《化学研究与应用》2005年第4期460-463,共4页Chemical Research and Application

基　　金：国家自然科学基金资助项目(29875017)

摘　　要：在0.2mol/L KH2PO4-Na2HPO4(pH5.5±0.1)支持电解质中,奥沙普秦产生一催化氢波,峰电位Ep＝-1.25V(vs.SCE).当1×10-2mol/LH2O2存在时,该催化氢波的峰电流增加12倍,峰电位基本不变,产生一较灵敏的平行催化氢波.其二阶导数峰峰电流ip″与奥沙普秦浓度在1.0×10-7～2.6×10-5mol/L范围内呈线性关系(r＝0.9995,n＝10),检出限为5.0×10-8mol/L.该方法可用于药物制剂中奥沙普秦含量的测定.A catalytic hydrogen wave of oxaprozin appears at ca.-1.25（vs. SCE）in 0. 2mol/L KH2PO4-Na2HPO4（pH5. 5±0.1）supporting electrolyte. When 1×10^-2mol/L H2O2 is present, the peak current of the catalytic hydrogen wave increases by 12 times,and the peak petentioal is unchanged,producing a more sensitive parallel catalytic hydrogen wave. The second-order different peak current of the parallel catalytic hydrogen wave is rectilinear to oxaprozincon centration in the range 1.0×10^-7～2.6×10^-5mol/L（r =0.9995 ,n=10）. The detection limit is 5.0×10^-8mol/L. The proposed method can be applied to the determination of oxaprozin in pharmaceuticals without preliminary separation.

关 键 词：奥沙普秦 过氧化氢 催化氢波 平行催化氢波 单扫描示波极谱法 

分 类 号：O657.14[理学—分析化学]