电刺激兔尾核头部对中脑网状结构痛敏神经元电活动的影响及与针效关系  

THE EFFECT OF ELECTRICAL STIMULATION OF THE HEAD OF CAUDATE NOCIICEPTIVE NEURONAL ACTIVITIES IN THE MESENCEPHALON RETICULAR FORMATION AND ITS RELATION TO THE ACUPUNCTURE EFFECT

作　　者：高美兰[1] 张均明[1] 刘荫仁[1] 

机构地区：[1]广西医学院生理教研室针麻基础研究室

出　　处：《针刺研究》1989年第4期414-419,共6页Acupuncture Research

摘　　要：尾核是锥体外系中与针刺镇痛有密切关系的一个结构,刺激尾核可产生镇痛作用,损毁尾核头部可减弱针刺镇痛,电刺激“合谷”时可在尾核记录到诱发电位,刺激人脑尾核头部能缓解晚期肿瘤病人的恶痛。本室曾证实。38 rabbits were anesthetized with chloralose and urethane. As soon as the animal recovered its consciousness it was immobilized with flaxedil and artificial respiration. The electrical activities of the nociceptive neurons were recorded by glass microelectrodes (tip 1-3μm) in the ranges P7-11 R2-3 HO^+ 1-6, with the aid of a stereotaxic apparatus. 116 of the nociceptive units responded to noxious stimuli which applied to the peroneal nerve with a short train of pulses. Among them, 64 units (55%)responded by an increase in frequency of the discharge to noxious stimuli (pain-excition neuron, PEN). In contrast, there were 52 units (45%), which responded to noxious stimuli quite differently, by having a decrease in the frequency of the discharge (pain-inhibition neuron, PIN). Similar results were obtaingd by the stimulation of the head of caudate nucleus with the same train of pulses: an ex-citatory effect was observed in PEN. and an inhibitory effect in PIN. However,after electroacupuncture by penetrating acupoint 'Hegu' or dolantin given intra-ven ously, under the same conditions used above. We again stimulated both the head of caudate nucleus, eliciting an inhibitory effect on PEN. And a reduction of inhibition or release from it on PIN. From the results presented, it indicated that head of caudate nucleus was connected with the modultion of the nociceptive neuronal activity in M. R. F. and was related to the effect of acupuncture. The effect of atropine on the head of caudate nucleus stimulation. The in-hibitory effect of the head of caudate nucleus on the nociceptive nucleus on thenociceptive discharges was diminished or cancelled by injection of atropine (0.3-0.5mg/kg i. v.). This suggested that the cholinergic system in the caudate nucleus was also involved in the pain impulses in M. R. F.

关 键 词：电刺激 尾核 针刺镇痛 

分 类 号：R338.8[医药卫生—人体生理学]