草酸铂联合持续静脉注射5-FU为主方案治疗晚期胃癌近期疗效观察  

Oxaliplatin combined with cotinuous infusion of 5-FU for treatment of advanced gastric cancer

作　　者：钱开军[1] 王军[1] 陈小飞[2] 易竹筠[2] 

机构地区：[1]淮安市第一人民医院分院,江苏淮安223002 [2]淮安市第一人民医院,江苏淮安223002

出　　处：《中国现代应用药学》2005年第4期349-350,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的观察草酸铂(L-OHP)联合持续静脉注射5-FU为主方案治疗晚期胃癌近期疗效观察.方法晚期胃癌23例.采用L-OHP 75mg/m2加葡萄糖注射静脉注射第1天、第8天,甲酰四氢叶酸钙(CF)100mg/m2静滴第1～5天,足乙叶苷(Vp-16)100mg静滴第1～3天,5-FU 500mg/m2持续静脉滴注120h,每3～4周,2个周期化疗后进行临床评价.结果完全缓解(CR)2例,部分缓解(PR)12例,总有效率60.9%,不良反应主要为Ⅰ、Ⅱ度白细胞下降及Ⅰ度周围神经毒性.结论 L-OHP联合持续静脉注射5-FU为主方案治疗晚期胃癌疗效好,不良反应轻,患者能耐受,是一种安全有效的化疗方案.OBJECTIVE To observe the short-term respose of combination infusion of 5-FU with oxaliplatin （L-OHP） in advanced gastric cancer, METHODS 23 patients with advanced gastric cancer using randomized method, L-OHP：75mg/m^2 , iv infusios 3 hours,d1.8; LV 100mg/m^2 ,iv infusion d1-5 ;VP-16：100mg,iv infusion d1-3 ;5-FU 500mg/m^2 mcontinuous infusion 120 hours 3-4 weeks is a cycle, 2 cycles were carried out. RESULTS The response rate was 60, 9% （14/23）. The major toxic effect were myelosuppression（ grade Ⅰ - Ⅱ ） and peripheral neuropathy toxicty（ grade Ⅰ ）. CONCLUSION L-OHP ＋ CF ＋ VP-16 ＋ 5-FU regimen is effective and well tolerable for advanced gastric cancer.

关 键 词：草酸铂 持续静脉注射 5-氟脉嘧啶 晚期胃癌 

分 类 号：R979.1[医药卫生—药品]