原发性高血压血栓前状态分子标志物的研究  

A study on molecular markers in prothrombotic state of essential hypertension

作　　者：马宏[1] 张七一[1] 

机构地区：[1]青岛市市立医院,266011

出　　处：《山西医药杂志》2005年第8期628-631,共4页Shanxi Medical Journal

摘　　要：目的通过测定原发性高血压患者血浆中血栓调节蛋白(TM)、血管性血友病因子(VWF)、纤溶酶原激活剂抑制物-1(PAI-1)的水平变化,以探讨内皮损伤的分子标志物与原发性高血压发生血栓性疾病的关系。方法应用酶联免疫吸附法(ELISA)分别测定98例原发性高血压患者和36名健康对照者血浆TM、VWF、PAI-1的水平变化,并对不同分级的原发性高血压患者的上述指标进行比较。结果与正常对照组比较,1、2、3级高血压组VWF、PAI-1水平显著增高(P<0.05),2、3级高血压组TM水平显著增高(P<0.05),与1级高血压组比较,2、3级高血压组TM、VWF、PAI-1水平显著增高(P<0.05)。结论原发性高血压病患者存在的血管内皮损伤、抗凝作用减弱、血小板黏附与聚集、纤溶活性的下降,可能是其并发心、脑血管血栓性并发症的原因之一。Objective To investigate the changes of plasma thrombomodulin （TM）, von Willebrand factor （VWF） and plasminogen activator inhibitor type I （PA1-1） in essential hypertensive patients and to discuss the relationship between the molecular markers of endothelial dysfunction and the complications of thromboembolism in essential hypertension（EH）. Methods The plasma concentrations of TM, VWF, PA1-1 were measured by ELISA in 98 patients with essential hypertension and 36 healthy controls. Results Compared with healthy controls, the levels of plasma VWF, PA1-1 were significantly higher in EH patients of grade 1,2, or 3 （P〈0.05）, the levels of plasma TM were significantly higher in EH patients of grade 2 ,or 3 group （P〈0.05）. Compared with grade-1 group, the levels of plasma TM,VWF,PA1-1 were significantly higher in EH patients of grade 2,3 groups （P〈0.05）.Conclusion Essential hypertensive patients had angioendothelial injury, reduced anticoagulation, platelet adhesiveness and aggregation, as well as decreased fibrinolytic activity, which may be the pathogenesis of complications such as ischemic stroke, heart attacks.

关 键 词：血栓调节蛋白 纤溶酶原激活物抑制物-1 高血压 血管性血友病因子 原发性高血压患者 分子标志物 血栓前状态 纤溶酶原激活剂抑制物 血管内皮损伤 血栓性并发症 

分 类 号：R544.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学]