用肾皮质区ROI计算GFR评价尿路梗阻患者肾功能  

Evaluation of renal function in urinary obstruction by ^(99)Tc^m-DTPA imaging calculated GFR with renal cortecal ROI

作　　者：柴雪红[1] 李亚明[1] 高凡[2] 杨锦屏[3] 张键[4] 朱进[4] 

机构地区：[1]中国医科大学附属第一医院核医学科,沈阳现在110001 [2]锦州市中心医院泌尿外科 [3]锦州市中心医院肾内科 [4]锦州市中心医院核医学科

出　　处：《中华核医学杂志》2005年第4期232-234,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的探讨设定不同肾感兴趣区(ROI)计算肾小球滤过率(GFR)评价尿路梗阻患者肾功能改变的临床价值。方法采用99Tcm-DTPA肾动态显像,应用Gates法计算30例不同程度单侧上尿路梗阻患者在设定全肾ROI及肾皮质ROI时各自的GFR值,并与同期检测的患肾尿微量白蛋白(MAIb)进行相关性分析。结果随积水程度加深,由2种ROI计算的GFR均下降;设定全肾ROI时,重度与轻及中度积水组相比GFR显著降低(P<0.01);设定肾皮质ROI时,各组GFR组间差异均显著(P<0.01);随积水程度加重,各组尿MAlb显著升高(P<0.01);设定肾皮质ROI时,各组GFR与MAlb均显著相关。结论由肾皮质ROI计算GFR值可更灵敏、更准确地发现尿路梗阻肾功能改变。Objective to evaluate renal tunction in urinary obstruction by ^99Tc^m-DTPA renal dynamic imaging calculated glomerular filtration rate （ GFR ）. Methods The renal function of 30 cases with upper urinary tract obstruction were evaluated by GFR calculated with ^99Tc^m-DTPA renal dynamic imaging using two different region of interest （ ROI ） ： the whole renal ROI and the renal cortecal ROI, and were correlated with urinary albumin （Alb）. Results With the increasing severity of the hydronephrosis, the urinary Alb increased in both groups, while the two different ROI calculated GFR were decreased. Besides, the renal cortecal ROI method was much more negatively correlated with the urinary Alb level. Conclusion The GFR calculated by ^99Tc^m-DTPA renal dynamic imaging is a reliable parameter for detection of the damage of glomerular filtration function in obstructive urinary diseases and the GFR calculated by renal cortecal ROI may provide more sensitively and accurately.

关 键 词：尿道梗阻 放射性核素显像 肾小球滤过率 DTPA 肾功能改变 上尿路梗阻 ROI GFR ^99TC^M-DTPA肾动态显像 患者 

分 类 号：R691.2[医药卫生—泌尿科学]