^(131)Ⅰ治疗非毒性甲状腺肿的疗效观察  

The therapeutic effect of ^(131)Ⅰ for the treatment of nontoxic goiter

作　　者：陈跃[1] 邱陵[1] 张春银[1] 龙水清[1] 甘西伦[1] 

机构地区：[1]泸州医学院附属医院核医学科,646000

出　　处：《中华核医学杂志》2005年第4期239-241,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的探讨131Ⅰ治疗非毒性甲状腺肿的临床效果。方法非毒性甲状腺肿患者106例,经131Ⅰ按甲状腺质量2.96-7.03MBq/g治疗,随访观察3-36个月,用超声检查测定甲状腺大小,观察甲状腺缩小情况。结果非毒性甲状腺肿131Ⅰ治疗12个月后痊愈43.4%(46例),显效35.8%(38例),有效11.3%(12例),无效9.4%(10例),总有效率为90.6%(96/106例)。甲状腺质量由治疗前(86.5±20.3)g缩小到治疗后(40.3±13.6)g(P<0.01)。随访3-36个月后4.7%(5例)发生甲状腺功能减退症,3.8%(4例)发生甲状腺功能亢进症。结论131Ⅰ治疗非毒性甲状腺肿安全、简便、有效。Objective To investigate the therapeutic effects of ^131I for the treatment of nontoxic goiter. Methods 106 patients with nontoxic goiter were treated with 2.96 -7.03 MBq/g ^131I. The volume of thyroid was measured by ultrasound. Clinical responses were fellowed after 3 - 36 months. Results 12 months after treated with ^131I 46 cases （43.4%） were cured, 38 cases （ 35.8% ） were remarkably effective, 12 cases （11.3%） were effective and 10 cases （9.4%） were no response in total 106 cases with nontoxic goiter. The total effective rate was 90.6%. Goiter mass was decreased from （86.5 ± 20.3 ） g to （40.3 ± 13.6） g （ P 〈 0.01 ）. During follow-up from 3 to 36 months 4.7% （5/106） of cases became hypothyroidism and 3.8% （4/106） of cases occurred hyperthyroidism. Conclusion ^131I is an effective, simple and safe method for the treatment of nontoxic goiter.

关 键 词：甲状腺肿 放射疗法 碘放射性同位素 非毒性甲状腺肿 ^131I治疗 疗效观察 甲状腺功能减退症 甲状腺功能亢进症 甲状腺质量 随访观察 

分 类 号：R817.5[医药卫生—影像医学与核医学]