可降解自乳化聚氨酯微球的合成及性能研究  

Research on syntheses of degradable self-emulsified polyurethane microspheres

作　　者：张志斌[1] 唐昌伟[1] 王琦[2] 谷媛媛[1] 唐世海[2] 万昌秀[1] 

机构地区：[1]四川大学高分子科学与工程学院,四川成都610065 [2]西南交通大学生物工程系,四川成都610031

出　　处：《功能材料》2005年第8期1232-1234,共3页Journal of Functional Materials

基　　金：四川省应用基础研究资助项目(03JY029-059)

摘　　要：将预聚-扩链-中和-乳化法联合运用,一步合成出自乳化聚氨酯微球。研究了自乳化聚氨酯微球的合成条件。包括二异氰酸酯单体种类对微球形态的影响;异佛尔酮二异氰酸酯(IPDI)和聚丙二醇(PPG)单体配比对乳化效果的影响;乳化时间对微球形态的影响;反应温度、聚合时间和搅拌速度等对微球合成的影响。并以可降解的聚乳酸(PLA)取代部分PPG合成出可降解的自乳化聚氨酯微球,对其在磷酸缓冲液中的降解性进行了研究。通过IR及SEM对自乳化聚氨酯微球进行了表征,找出了合成稳定、均匀和形态好的自乳化聚氨酯微球的最佳条件。The self-emulsified polyurethane microspheres were synthesized by combining prepolymerization, chain-extension, neutralization and emulsification methods in one step. The synthetic conditions of self-emulsified polyurethane microspheres were researched. The conditions include the kinds of diisocyanates, the feed ratios of isophorone diisocyanate（IPDI） and polypropylene glycol （PPG）, emulsification time, reaction time, polymerization time and stirred velocity etc. And the conditions affected morphology of microsphere and emulsion stability, The degradable self-emulsified polyurethanes（SEPUL） were synthesized with IPDI, PPG and poly（lactic acid） （PLA）. And the degradation property was researched in phosphate buffer solution （PBS）. The structure and morphology of polyurethane microspheres were measured with infrared spectrum and scanning electron microscope. We found the best conditions to synthesize the stable,mean and globose self-emulsified polyurethane microsphere.

关 键 词：自乳化 聚氨酯微球 预聚-扩链-中和-乳化法 降解性能 

分 类 号：R318[医药卫生—生物医学工程]