全肠外营养和消炎痛对创伤后应激反应及蛋白质代谢的影响  

EFFECTS OF TPN AND INDOMETHACIN ON STRESS RESPONSE AND PROTEIN METABOLISM AFTER SURGERY

作　　者：全竹富[1] 黎介寿[1] 刘福坤[1] 盛学勤[1] 

机构地区：[1]南京军区南京总医院

出　　处：《解放军医学杂志》1995年第1期24-26,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：比较了全肠外营养（ＴＰＮ）和消炎痛对创伤性应激反应和蛋白质代谢的影响。将１９例因贲门癌行经腹根治性全胃切除的中等创伤病人，分为对照组、全肠外营养（ＴＰＮ）组和消炎痛组，监测了体温、血浆蛋白、应激激素、尿中尿素氮、肌酐和３－甲基组氨酸的变化。结果发现：ＴＰＮ组病人血浆Ｃ－反应蛋白、儿茶酚胺、皮质醇、胰岛素均增高；消炎痛组病人体温降低，儿茶酚胺和皮质醇升高不明显，尿中尿素氮和３－甲基组氨酸排出减少。说明ＴＰＮ能促进蛋白质合成，消炎痛能减轻应激反应，抑制蛋白质分解。The study was planned to evaluate effects of TPN and indomethacin on stress response af-ter trauma, and protein metabolism in patients who had received total gastrectomy for cardiac cancer ofstomach. 19 cases was divided into control ,TPN,and indomethacin groups. Body temperature,plasma pro-teins , stress hormones andurinarv excretion of BUN, Cr and3-MH were determined. The result showedthat plasma C-reactive protein, insulin and nitrogen retention were significantly increased in TPN group,and that body temperature,plasma levels of cortisol and catecholamine,and urinary excretion of UBN and3-MH were remarkably decreased in indomethacin group. It is conclued that TPN could promote proteinsynthesis and nitrogen balance,and that indomethacin might reduce stress response and protein catabolismIn traumatic patients

关 键 词：全肠外营养 创伤 应激反应 蛋白质 吲哚氯甲酰 

分 类 号：R459.3[医药卫生—治疗学] R641[医药卫生—临床医学]