地塞米松对穿支皮瓣成活率的影响  

Effect of dexamethasone on the perforator flap

作　　者：冯瑞铮[1] 杨时昕[2] 董佳生[1] 

机构地区：[1]上海第二医科大学附属第九人民医院整形外科,上海200011 [2]山西医科大学第一临床医学院整形外科

出　　处：《山西医科大学学报》2005年第4期404-407,共4页Journal of Shanxi Medical University

摘　　要：目的研究局部应用地塞米松对大鼠腹部穿支皮瓣成活率的影响。方法建立大鼠腹壁上动脉穿支皮瓣动物模型,随机分为2组,实验组术后皮瓣内注射地塞米松磷酸钠注射液(5mg/ml)0.2ml,对照组注射0.9%生理盐水0.2ml,术后24h、48h重复注射。术后1,2,3,7d取材,测定皮瓣坏死率和组织中超氧化物歧化酶(SOD)活力、丙二醛(MDA)和一氧化氮(NO)的含量。结果实验组皮瓣坏死率较对照组显著降低(P<0.01),SOD活力较对照组明显提高(P<0.05),而MDA和NO含量则降低(P<0.05)。结论局部应用地塞米松能提高穿支皮瓣的成活率。Objective To investigate the effect of dexamethasone on the perforator flap. Methods The aromal model of the abdominal perforator flap in rats was set up. After operation, dexamethasone, at dose （5 mg/ml）0.2 ml was injected under the flap,24 and 48 h later it was injected again. 1,2,3,7 d later, the necrosis rate and content of SOD, MDA and NO were determined respectively. Results Compared with control group, the necrosis rate and the contents of MDA and NO in the dexamethasone group decreased significantly（P（0.05）,the content of SOD increased significantly（P〈0.05）. Conclusion Dexarnethasone can improve the survival of the perforator flap.

关 键 词：皮瓣 地塞米松 大鼠 

分 类 号：R622.1[医药卫生—整形外科]