儿童单纯性肥胖症综合干预前后内皮素及血脂的变化  

Changes of serum endothelin and cholesterolemia in simple obesity children before and after comprehensive intervention

作　　者：李志鸿[1] 李新景[1] 

机构地区：[1]山西医科大学第一临床医学院儿科,太原030001

出　　处：《山西医科大学学报》2005年第4期506-508,共3页Journal of Shanxi Medical University

基　　金：山西省科技厅科研基金资助项目(200035)

摘　　要：目的探讨单纯性肥胖症儿童综合干预前后内皮素及血脂改变的特点。方法收集7～14岁单纯性肥胖症儿童30例(肥胖组),正常儿童30例(对照组)。肥胖组进行为期6个月的综合干预,包括行为干预、膳食调整、运动锻炼,测定其综合干预前、后的内皮素、血脂、体重等指标,测定对照组儿童的内皮素及血脂。结果肥胖组儿童的内皮素、血脂明显升高,与对照组比较,差异有显著性(P<0.01)。综合干预后肥胖组儿童自身比较体重下降(P<0.01),与干预前比较,差异有显著性(P<0.01)。结论单纯性肥胖症儿童内皮素及血脂增高,而综合干预能使其降低。Objective To observe the changes of the blood endothdin （ET） and hypercholesterolemia in simple obesity children before and after comprehensive intervention. Methods Thirty children with obesity （group A） and 30 normal children （group B） aged 7 to 14 years were enrolled. Group A received comprehensive intervention for 6 months, including balance diet, exercise and behavior intervention. Blood levels of ET, hypercholesterolemia and body-weigt were measured and compared with their pre-intervention state and with group B. Results Levels of ET, TG, TC, LDL and apoB were significantly higher, while the levels of HDL and apoA were lower in group A than in group B. There was significant difference （ P 〈 0.01 ）. After comprehensive intervention, levels of ET, TG, TC and apoB decreased, while HDL and apoA increased significantly compared with those before intervention in group A（ P〈0.01）. Conclusion The serum levels of ET and cholesterolemia are increased in the obesity children,indicating the childrens＇ obesity decreased by comprehensive intervention.

关 键 词：肥胖症 儿童 内皮缩血管肽类 高胆固醇血症 综合干预 

分 类 号：R723.14[医药卫生—儿科]