39例乙型肝炎病毒相关性肾炎临床与病理分析  

Clinicopathological features of 39 cases with Hepatitis B-associated glomerulonephritis

作　　者：蔡玉梅 沈世忠[2] 吴建平[2] 杨维群 

机构地区：[1]泉州卫生学校病理教研室,362000 [2]泉州市第一医院肾内科,362000

出　　处：《福建医药杂志》2005年第4期32-34,共3页Fujian Medical Journal

摘　　要：目的探讨泉州市乙型肝炎病毒相关性肾炎(HBV-GN)的临床、病理特点。方法分析39例HBV-GN的临床病理、免疫组化特点。结果39例HBV-GN的临床表现以肾病综合征最常见(59%),其次是肾炎综合征(24%)和无症状性血尿和/或蛋白尿(17.1%)。病理类型多样化,膜性肾病(MNGN)、青少年MNGN(≤16岁)、非IgA系膜增生性肾小球肾炎(MsPGN)、系膜毛细血管性肾炎(MPGN)、IgA肾病(IgAN)和毛细血管内增生性肾小球肾炎(EPGN)分别占41%、64.7%、28.2%、10.3%、17.2%和2.6%。结论HBV-GN的病理类型主要以MNGN和MsPGN多见,HBVAg免疫组化标记是诊断HBV-GN的重要指标。Objective To explore the clinical and pathological feature of hepatitis B virus associated glomerulonephritis （HBV-GN） in Quanzhou. Methods Thirty-nine cases with HBV-GN were confirmed by renal biopsy. Clinicopathologic and immunohistochemical characters of these cases were analyzed. Results The clinicopathologic manifestation of HBV-GN was various. Nephritic syndrome （NS） was the mostly encountered clinical manifestation with the rate of 59%. The second were nephritic sydrorne and asymptomatic proteinuria with or without hematuria, with respective rate of 24% and 17.1 %. The most common pathological types of HBV-GN were membranous nephropathy （MNGN）, with the rate of 41%. In those cases, MNGN of teenagers （≤16 years） were 64.7%o. The second were non IgA-mesangical proliferative glomerulonephritis, with the rate of 28.2%. mesangiocapillary glomerulone phritis （MPGN）, IgA nephropathy （IgAN） and endocapillary proliferative glomerulonephritis （EPGN） was respectively 10.3%, 17.2% and 2.6%. Conclusion Main pathological type of HBV-GN in Quanzhou is MNGN and MsPGN. MNGN of HBV-GN is more common in teenagers. Immunohistochemical markers of HBV antigen are important criteria for diagnosis of HBN GN.

关 键 词：乙型肝炎病毒 肾炎 病理 临床 

分 类 号：R512.62[医药卫生—内科学] R692.3[医药卫生—临床医学]