老年鼠皮质内胆硷能纤维损伤后的再生和抽芽  

REGENERATION AND SPROUTING OF CHOLINERGIC FIBERS IN CEREBRAL CORTEX OF AGED RATS

作　　者：龙大宏[1] 姚志彬[1] 

机构地区：[1]中山医科大学解剖学教研室和脑研究室,广州510089

出　　处：《解剖学杂志》1995年第2期128-132,共5页Chinese Journal of Anatomy

摘　　要：老年SD大鼠(24月龄)顶皮质切一宽2mm的冠状切口,用染色AChE纤维的组织化学方法分析术后1、2、3,4、5、8周切口嘴、尾侧区的胆硷能纤维的再生和抽芽状况.结果显示损伤后切口嘴侧纤维先轻度减少,然后迅速增加超过正常22.6%,并沿切口嘴侧缘形成密集的AChE阳性纤维丛;损伤后第1周切口尾侧纤维显著减少,相当于正常的22.3%,从第2周开始纤维数量逐渐增加,到8周时恢复到正常的82.7%;并发现少量纤维直接穿过切口进入尾侧区.提示老年哺乳类皮质胆硷能纤维有一定的再生和侧支抽芽能力.A 2 - mm coronal incision was made in the cerebral cortex of aged rats. The cholinergic axonal regeneration and sprouting were assessed by acetylcholinesterase histochemistry at 1,2, 3,4,5 and 8 weeks after the operation. In the area rostral to the incision cholinergic fibers reduced at first, and then increased quickly and exceeded over the normal level. A dense fiber plexus was observed along the wound margin in the area rostral to the incison. In caudal areas AChE-position fibers were reduced obviously at the first week but increased with time and a few fibers grew across the lesion. The results revealed that the cholinergic fibers in cerebral cortex of aged mammalian could regrow and spout after lesion.

关 键 词：胆硷能神经纤维 大脑皮质 再生 老年 大鼠 

分 类 号：R322.85[医药卫生—人体解剖和组织胚胎学] Q959.837[医药卫生—基础医学]