In Vitro Degradation of Polyglycolide/Chitosan Hybrid Braids  

作　　者：袁晓燕 张庆伟 望咏林 姚康德 

机构地区：[1]School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China

出　　处：《Transactions of Tianjin University》2005年第4期235-239,共5页天津大学学报（英文版）

基　　金：Supported by the Cooperative Project Between Nankai University and Tianjin University, Ministry of Education;Scientific Research Starting Fund for Homecoming Scholars, Ministry of Education.

摘　　要：Hybrid braids of polyglycolide （PGA） and chitosan were prepared by the three-yarn braiding method from PGA and chitosan fiber bundles. These braids were in vitro degraded by incubating them in phosphate buffered saline （ PBS ） at pH 7.4 and 37℃ for 5 weeks. Results suggested that PGA/chitosan hybrid braids degraded significantly. Scanning electron micrographs showed that chitosan fibers in the PGA/chitosan hybrid braid with about 75% PGA in weight （ PGA75/chitosan ）were shaped into gel-like after 5 weeks, but those in the hybrid braid with about 25% PGA in weight（PGA25/chitosan） did not change. After 5 weeks, the ultimate tensile loads of PGA and PGA75/chitosan braids lost almost completely, but those of chitosan and PGA25/chitosan braids remained around 14 N. The PGA/chitosan hybrid braids with higher initial ultimate tensile load would have potential applications in tendon/ligament tissue reconstruction.Hybrid braids of polyglycolide （PGA） and chitosan were prepared by the three-yarn braiding method from PGA and chitosan fiber bundles. These braids were in vitro degraded by incubating them in phosphate buffered saline （PBS） at pH 7.4 and 37 ℃ for 5 weeks. Results suggested that PGA/chitosan hybrid braids degraded significantly. Scanning electron micrographs showed that chitosan fibers in the PGA/chitosan hybrid braid with about 7500 PGA in weight （PGA75/chitosan） were shaped into gel-like after 5 weeks, but those in the hybrid braid with about 2500 PGA in weight （PGA25/chitosan） did not change. After 5 weeks, the ultimate tensile loads of PGA and PGA75/chitosan braids lost almost completely, but those of chitosan and PGA25/chitosan braids remained around 14 N. The PGA/chitosan hybrid braids with higher initial ultimate tensile load would have potential applications in tendon/ligament tissue reconstruction.

关 键 词：polyglycolide ： chitosan ： hybrid braid in vitro degradation 

分 类 号：TB322[一般工业技术—材料科学与工程]